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Ethnic differences in COVID-19 mortality during the first two waves of the Coronavirus Pandemic: a nationwide cohort study of 29 million adults in England

Ethnic differences in COVID-19 mortality during the first two waves of the Coronavirus Pandemic: a nationwide cohort study of 29 million adults in England
Ethnic differences in COVID-19 mortality during the first two waves of the Coronavirus Pandemic: a nationwide cohort study of 29 million adults in England
Ethnic minorities have experienced disproportionate COVID-19 mortality rates in the UK and many other countries. We compared the differences in the risk of COVID-19 related death between ethnic groups in the first and second waves the of COVID-19 pandemic in England. We also investigated whether the factors explaining differences in COVID-19 death between ethnic groups changed between the two waves. Using data from the Office for National Statistics Public Health Data Asset, a linked dataset combining the 2011 Census with primary care and hospital records and death registrations, we conducted an observational cohort study to examine differences in the risk of death involving COVID-19 between ethnic groups in the first wave (from 24th January 2020 until 31st August 2020) and the first part of the second wave (from 1st September to 28th December 2020). We estimated age-standardised mortality rates (ASMR) in the two waves stratified by ethnic groups and sex. We also estimated hazard ratios (HRs) for ethnic-minority groups compared with the White British population, adjusted for geographical factors, socio-demographic characteristics, and pre-pandemic health conditions. The study population included over 28.9 million individuals aged 30–100 years living in private households. In the first wave, all ethnic minority groups had a higher risk of COVID-19 related death compared to the White British population. In the second wave, the risk of COVID-19 death remained elevated for people from Pakistani (ASMR: 339.9 [95% CI: 303.7–376.2] and 166.8 [141.7–191.9] deaths per 100,000 population in men and women) and Bangladeshi (318.7 [247.4–390.1] and 127.1 [91.1–171.3] in men and women) background but not for people from Black ethnic groups. Adjustment for geographical factors explained a large proportion of the differences in COVID-19 mortality in the first wave but not in the second wave. Despite an attenuation of the elevated risk of COVID-19 mortality after adjusting for sociodemographic characteristics and health status, the risk was substantially higher in people from Bangladeshi and Pakistani background in both the first and the second waves. Between the first and second waves of the pandemic, the reduction in the difference in COVID-19 mortality between people from Black ethnic background and people from the White British group shows that ethnic inequalities in COVID-19 mortality can be addressed. The continued higher rate of mortality in people from Bangladeshi and Pakistani background is alarming and requires focused public health campaign and policy changes.
0393-2990
605-617
Nafilyan, Vahe
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Islam, Nazrul
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Mathur, Rohini
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Ayoubkhani, Daniel
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Banerjee, Amitava
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Glickman, Myer
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Humberstone, Ben
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DIamond, Ian
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Khunti, Kamlesh
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Nafilyan, Vahe
542d70f5-e4b4-4b4c-b9f6-5b039999f8e9
Islam, Nazrul
e5345196-7479-438f-b4f6-c372d2135586
Mathur, Rohini
989febb1-9d36-4ce0-8690-3b163a385dd3
Ayoubkhani, Daniel
cfd1b0e2-6685-4edb-a53f-299582b89280
Banerjee, Amitava
9dc019f6-f475-4fca-be07-8967115af995
Glickman, Myer
61b66cbc-a403-4cd6-b7b5-eb18fccae968
Humberstone, Ben
e3a39bfb-dc0e-4d3b-82aa-e1d018fc6f82
DIamond, Ian
d22d5718-784f-4212-9f1a-01cdbb95a337
Khunti, Kamlesh
3e64e5f4-0cc9-4524-aa98-3c74c25101c3

Nafilyan, Vahe, Islam, Nazrul, Mathur, Rohini, Ayoubkhani, Daniel, Banerjee, Amitava, Glickman, Myer, Humberstone, Ben, DIamond, Ian and Khunti, Kamlesh (2021) Ethnic differences in COVID-19 mortality during the first two waves of the Coronavirus Pandemic: a nationwide cohort study of 29 million adults in England. European Journal of Epidemiology, 36 (6), 605-617. (doi:10.1101/2021.02.03.21251004).

Record type: Article

Abstract

Ethnic minorities have experienced disproportionate COVID-19 mortality rates in the UK and many other countries. We compared the differences in the risk of COVID-19 related death between ethnic groups in the first and second waves the of COVID-19 pandemic in England. We also investigated whether the factors explaining differences in COVID-19 death between ethnic groups changed between the two waves. Using data from the Office for National Statistics Public Health Data Asset, a linked dataset combining the 2011 Census with primary care and hospital records and death registrations, we conducted an observational cohort study to examine differences in the risk of death involving COVID-19 between ethnic groups in the first wave (from 24th January 2020 until 31st August 2020) and the first part of the second wave (from 1st September to 28th December 2020). We estimated age-standardised mortality rates (ASMR) in the two waves stratified by ethnic groups and sex. We also estimated hazard ratios (HRs) for ethnic-minority groups compared with the White British population, adjusted for geographical factors, socio-demographic characteristics, and pre-pandemic health conditions. The study population included over 28.9 million individuals aged 30–100 years living in private households. In the first wave, all ethnic minority groups had a higher risk of COVID-19 related death compared to the White British population. In the second wave, the risk of COVID-19 death remained elevated for people from Pakistani (ASMR: 339.9 [95% CI: 303.7–376.2] and 166.8 [141.7–191.9] deaths per 100,000 population in men and women) and Bangladeshi (318.7 [247.4–390.1] and 127.1 [91.1–171.3] in men and women) background but not for people from Black ethnic groups. Adjustment for geographical factors explained a large proportion of the differences in COVID-19 mortality in the first wave but not in the second wave. Despite an attenuation of the elevated risk of COVID-19 mortality after adjusting for sociodemographic characteristics and health status, the risk was substantially higher in people from Bangladeshi and Pakistani background in both the first and the second waves. Between the first and second waves of the pandemic, the reduction in the difference in COVID-19 mortality between people from Black ethnic background and people from the White British group shows that ethnic inequalities in COVID-19 mortality can be addressed. The continued higher rate of mortality in people from Bangladeshi and Pakistani background is alarming and requires focused public health campaign and policy changes.

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Accepted/In Press date: 21 May 2021
Published date: 16 June 2021

Identifiers

Local EPrints ID: 470571
URI: http://eprints.soton.ac.uk/id/eprint/470571
ISSN: 0393-2990
PURE UUID: a3134778-7e6c-4457-88af-a3ebe6237aac
ORCID for Nazrul Islam: ORCID iD orcid.org/0000-0003-3982-4325

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Date deposited: 13 Oct 2022 16:36
Last modified: 17 Mar 2024 04:15

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Contributors

Author: Vahe Nafilyan
Author: Nazrul Islam ORCID iD
Author: Rohini Mathur
Author: Daniel Ayoubkhani
Author: Amitava Banerjee
Author: Myer Glickman
Author: Ben Humberstone
Author: Ian DIamond
Author: Kamlesh Khunti

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