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Obesity, ethnicity, and risk of critical care, mechanical ventilation, and mortality in patients admitted to hospital with COVID-19: Analysis of the ISARIC CCP-UK cohort

Obesity, ethnicity, and risk of critical care, mechanical ventilation, and mortality in patients admitted to hospital with COVID-19: Analysis of the ISARIC CCP-UK cohort
Obesity, ethnicity, and risk of critical care, mechanical ventilation, and mortality in patients admitted to hospital with COVID-19: Analysis of the ISARIC CCP-UK cohort

Objective: the aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups.

Methods: patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases.

Results: of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity.

Conclusions: obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

Adult, Aged, COVID-19/ethnology, Cohort Studies, Comorbidity, Critical Care/statistics & numerical data, Ethnicity/statistics & numerical data, Female, Hospital Mortality, Hospitalization/statistics & numerical data, Humans, Male, Middle Aged, Minority Groups/statistics & numerical data, Obesity/ethnology, Odds Ratio, Respiration, Artificial/statistics & numerical data, United Kingdom, Young Adult
1930-7381
1223-1230
Yates, Thomas
dce0546a-5b14-41b5-b1a2-b78a9057389b
Zaccardi, Francesco
8d31a980-3db1-4477-9514-c18087cf886a
Islam, Nazrul
e5345196-7479-438f-b4f6-c372d2135586
Razieh, Cameron
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Gillies, Clare L.
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Lawson, Claire A.
631da820-36df-4ffd-ab81-a76953a83eb2
Chudasama, Yogini
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Rowlands, Alex
97bdaa98-c663-4c8e-a409-ec7d4e1f22dc
Davies, Melanie J.
f23a2532-1297-4ee3-93d1-8387ab98e151
Docherty, Annemarie B.
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Openshaw, Peter J.M.
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Baillie, J. Kenneth
a08f7c7f-62a3-44ea-af0e-aa5f1ffde00c
Semple, Malcolm G.
15b207df-e044-4078-9b40-1af17b800ab1
Khunti, Kamlesh
3e64e5f4-0cc9-4524-aa98-3c74c25101c3
Yates, Thomas
dce0546a-5b14-41b5-b1a2-b78a9057389b
Zaccardi, Francesco
8d31a980-3db1-4477-9514-c18087cf886a
Islam, Nazrul
e5345196-7479-438f-b4f6-c372d2135586
Razieh, Cameron
1f2cef7c-20b4-4edc-9533-c34fed0bfc13
Gillies, Clare L.
fc26555a-79f4-4d0e-9a34-1dc4fbda4be9
Lawson, Claire A.
631da820-36df-4ffd-ab81-a76953a83eb2
Chudasama, Yogini
8026abd3-900a-4b96-8d5f-2ef59496929e
Rowlands, Alex
97bdaa98-c663-4c8e-a409-ec7d4e1f22dc
Davies, Melanie J.
f23a2532-1297-4ee3-93d1-8387ab98e151
Docherty, Annemarie B.
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Openshaw, Peter J.M.
4e1ec99b-8f41-4740-be78-a57b2361d483
Baillie, J. Kenneth
a08f7c7f-62a3-44ea-af0e-aa5f1ffde00c
Semple, Malcolm G.
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Khunti, Kamlesh
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Yates, Thomas, Zaccardi, Francesco, Islam, Nazrul, Razieh, Cameron, Gillies, Clare L., Lawson, Claire A., Chudasama, Yogini, Rowlands, Alex, Davies, Melanie J., Docherty, Annemarie B., Openshaw, Peter J.M., Baillie, J. Kenneth, Semple, Malcolm G. and Khunti, Kamlesh (2021) Obesity, ethnicity, and risk of critical care, mechanical ventilation, and mortality in patients admitted to hospital with COVID-19: Analysis of the ISARIC CCP-UK cohort. Obesity, 29 (7), 1223-1230. (doi:10.1002/oby.23178).

Record type: Article

Abstract

Objective: the aim of this study was to investigate the association of obesity with in-hospital coronavirus disease 2019 (COVID-19) outcomes in different ethnic groups.

Methods: patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from February 6 to October 12, 2020. Ethnicity was classified as White, South Asian, Black, and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation, and in-hospital mortality, adjusted for age, sex, and chronic diseases.

Results: of the participants included, 54,254 (age = 76 years; 45.0% women) were White, 3,728 (57 years; 41.1% women) were South Asian, 2,523 (58 years; 44.9% women) were Black, and 5,427 (61 years; 40.8% women) were other ethnicities. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the odds ratios for admission to critical care, mechanical ventilation, and mortality in black ethnicities with obesity were 3.91 (3.13-4.88), 5.03 (3.94-6.63), and 1.93 (1.49-2.51), respectively, compared with White ethnicities without obesity.

Conclusions: obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in Black ethnicities.

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Obesity - 2021 - Yates - Obesity Ethnicity and Risk of Critical Care Mechanical Ventilation and Mortality in Patients - Version of Record
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Accepted/In Press date: 17 March 2021
e-pub ahead of print date: 14 May 2021
Additional Information: © 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).
Keywords: Adult, Aged, COVID-19/ethnology, Cohort Studies, Comorbidity, Critical Care/statistics & numerical data, Ethnicity/statistics & numerical data, Female, Hospital Mortality, Hospitalization/statistics & numerical data, Humans, Male, Middle Aged, Minority Groups/statistics & numerical data, Obesity/ethnology, Odds Ratio, Respiration, Artificial/statistics & numerical data, United Kingdom, Young Adult

Identifiers

Local EPrints ID: 470582
URI: http://eprints.soton.ac.uk/id/eprint/470582
ISSN: 1930-7381
PURE UUID: 021be9ea-6791-4d2d-a7de-74bf37d7c1d6
ORCID for Nazrul Islam: ORCID iD orcid.org/0000-0003-3982-4325

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Date deposited: 13 Oct 2022 16:42
Last modified: 17 Mar 2024 04:15

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Contributors

Author: Thomas Yates
Author: Francesco Zaccardi
Author: Nazrul Islam ORCID iD
Author: Cameron Razieh
Author: Clare L. Gillies
Author: Claire A. Lawson
Author: Yogini Chudasama
Author: Alex Rowlands
Author: Melanie J. Davies
Author: Annemarie B. Docherty
Author: Peter J.M. Openshaw
Author: J. Kenneth Baillie
Author: Malcolm G. Semple
Author: Kamlesh Khunti

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