RAD51 135G→C modifies breast cancer risk among BRCA2 mutation carriers: Results from a combined analysis of 19 studies

Accepted/In Press date: 2 August 2007

Published date: 9 January 2008

Additional Information: Funding Information: A.C.A., C.B., M.C., S.P., the CIMBA data management, and EMBRACE are funded by Cancer Research UK. D.F.E. is a Principal Research Fellow of Cancer Research UK. The GEMO study was supported by the Programme Hospitalier de Recherche Clinique grant AOR01082, by the Programme Incitatif et Coopératif Génétique et Biologie de Cancer du Sein, Institut Curie, and by the Association “Le cancer du sein, parlons-en!” Award. This publication was supported in part by revenue from Nebraska cigarette taxes awarded to Creighton University by the Nebraska Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the State of Nebraska or the Nebraska Department of Health and Human Services. Support was also received from National Institutes of Health (NIH) grants 5UO1 CA86389 (to H.T.L.), R01-CA083855 (to S.L.N.), R01-CA74415 (to S.L.N.), R01-CA102776 (to T.R.R.), and R01-CA083855 (to T.R.R.). Sample collection and participation for J.W. was supported in part by a General Clinical Research Center grant from the NIH (MO1 RR00043) awarded to the City of Hope National Medical Center, Duarte, California. The EMBRACE team thanks C. Luccarini for technical assistance with the DNA samples. The GEMO collaborators thank Benjamin Bouchet and Gaël Grelier for their assistance with real-time PCR analysis. The GCHBOC is supported by German Cancer Aid grant 107054 and Center for Molecular Medicine Cologne grant TV 93 (to R.K.S.). GCHBOC acknowledges the contributions of Christian Sutter, Institute of Human Genetics, University of Heidelberg; Juergen Horst, Institute of Human Genetics, University of Muenster; Dieter Schaefer, Institute of Human Genetics, University of Frankfurt; Wera Hofmann, Division of Tumorgenetics, Max Delbrück Center for Molecular Medicine, Berlin; Karin Kast, Department of Gynecology and Obstetrics, University of Dresden; and Dorothea Gadzicki, Department of Human Genetics, Medical University, Hannover. kConFab thanks Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study (funded by National Health and Medical Research Council [NHMRC] grants 145684 and 288704), for their contributions to this resource, and the many families who contribute to kConFab. kConFab is supported by grants from the National Breast Cancer Foundation, NHMRC; the Queensland Cancer Fund; the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia; and the Cancer Foundation of Western Australia. The kConFab genotyping was supported by an NHMRC Programme grant (to G.C.T.). G.C.T. is an NHMRC Senior Principal Research Fellow, and A.B.S. is an NHMRC Career Development Award recipient. This research was supported in part by funding from the Intramural Research Program of the NIH, National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics, and the Center for Cancer Research, and by Clinical Genetic Branch’s support services contract NO2-CP-11019-50 with Westat. We acknowledge the long-term clinical support of Jennifer Loud, Ruthann Giusti, and Ron Kase and his staff, as well as Lutecia H. Mateus Pereira and Marbin A. Pineda for laboratory assistance. This work was supported by Cancer Care Ontario and Request For Application CA-95-003 as part of the NCI Breast Cancer Family Registries (to I.L.A.). This work was supported by the Canadian Institutes of Health Research for the INHERIT BRCAs program, the CURE Foundation, and the Fonds de la recherche en Santé du Quebec/Reseau de Medecine Genetique Appliquee. J.S. holds the Canada Research Chair in Oncogenetics. K.O. is supported by funding from Komen Foundation grant BCTR0601361, and T.K. holds a Frankel Fellowship. This work was partially funded by grants from the Israeli Cancer Association and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv (to E.F.). M.P.G.V. was supported by Dutch Cancer Society grant UL-2001-2471. We thank Hans Vasen, Hanne Meijers-Heijboer, and Christi van Asperen, for their ascertainment and blood sampling of breast cancer families, and Dieneke Biemans, for providing follow-up data. The Spanish Consortium for the Study of Genetic Modifiers of BRCA1 and BRCA2 (Spanish National Cancer Centre [CNIO]) was supported by the “Mutua Madrileña” and “Genoma España” foundations. We acknowledge Roger Milne, Rosario Alonso, Guillermo Pita, Jesús López, and Miguel Urioste for their assistance. HEBCS was supported by Academy of Finland grant 110663, the Finnish Cancer Society, the Helsinki University Central Hospital Research Fund, and the Sigrid Juselius Fund. We thank Drs. Kristiina Aittomäki, Carl Blomqvist, and Kirsimari Aaltonen, as well as Anitta Tamminen, for their kind help. For Modifier Study of Quantitative Effects on Disease (Mod-Squad), C.I.S. is partially supported by Susan G. Komen Foundation Basic, Clinical, and Translational Research grant BCTR0402923, Research Project of the Ministry of Education, Youth, and Sports of the Czech Republic grant MSM0021620808 (to M.Z., Zdenek Kleibl, and Petr Pohlreich). We acknowledge the contributions of Petr Pohlreich and Zdenek Kleibl (Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic) and Lenka Foretova, Machakova Eva, and Lukesova Miroslava (Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic) with the support of Ministry of Health grant CR-MZ0 MOU 2005. We thank Diana Torres and Muhammad U. Rashid for providing DNA samples and supplying data. We thank Antje Seidel-Renkert and Michael Gilbert for expert technical assistance. This work was supported in part by grants from the Breast Cancer Research Foundation, U.S. Army Medical Research and Materiel Command grant W81XWH-04-1-0588, and Mayo Clinic Breast Cancer Specialized Programs of Research Excellence grant P50-CA116201 (to F.J.C.). The Mayo Clinic study thanks Noralane Lindor and Linda Wadum for their contributions. ILUH collaborators are Rosa B. Barkardottir, Gudrun Johannesdottir, Bjarni A. Agnarsson, and Oskar T. Johannsson. ILUH was funded by the Science Fund of Landspitali-University Hospital and by the Memorial Fund of Bergthora Magnusdottir and Jakob Bjarnason.

Local EPrints ID: 470615

URI: http://eprints.soton.ac.uk/id/eprint/470615

DOI: doi:10.1086/522611

ISSN: 0002-9297

PURE UUID: c5cf7f12-5605-4a2e-8a16-2589e122d9f4

ORCID for Diana Eccles: orcid.org/0000-0002-9935-3169

ORCID for Anneke Lucassen: orcid.org/0000-0003-3324-4338

Date deposited: 14 Oct 2022 16:44

Last modified: 18 Mar 2024 02:54