Integrated genetic-map of human-chromosome-2

COX, S, BRYANT, SP, COLLINS, A, WEISSENBACH, J, DONISKELLER, H, KOELEMAN, BPC, STEINKASSERER, A and SPURR, NK (1995) Integrated genetic-map of human-chromosome-2. Annals of Human Genetics, 5459 (4), 414-434. (doi:10.1111/j.1469-1809.1995.tb00760.x).

Abstract

A framework genetic map of human chromosome 2 is described, integrating data from the Centre d'Étude du Polymorphisme Humain (CEPH) version 6 database, the CEPH chromosome 2 consortium database, the National Institute of Health (NIH)/CEPH Collaborative Mapping group and other laboratories. A comprehensive map is also presented, showing regional locations of a large number of additional loci. The framework map is used to identify an informative set of meiotic breakpoints within the CEPH families, and the utility of this information for mapping new markers is discussed. The degree of typing error within the data set is estimated, as are the sex-specific interference parameters. A location database for these genetic and additional cytogenetic data is constructed using algorithms which map genetic distances on to a physical scale, and the potential for this approach to aid the integration of genetic and physical data is examined.

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Contributors

Author: A COLLINS

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