Combined segregation and linkage analysis of 59 Hodgkin's disease families indicates the role of HLA determinants
Combined segregation and linkage analysis of 59 Hodgkin's disease families indicates the role of HLA determinants
Through a literature search, we identified a total of 59 nuclear families with Hodgkin's disease (HD). The affected individuals in these families were HLA haplotyped. To evaluate the role of HLA-linked determinants of HD and investigate the mode of inheritance of familial HD, a combined segregation and linkage analysis was performed, together with a semi-parametric analysis of sib pairs. Amongst single locus models, a general single locus model showed no improvement over an additive model. However, a two locus additive model gave the best overall fit and a lod score of 3.55. We conclude that HD is most likely to be determined by both an HLA-associated major gene and other non-HLA genetic factors together with environmental effects.
EBV, HLA, Hodgkin's disease, Linkage, Sib pairs
460-463
Shugart, Yin Yao
e3183e57-94cf-4009-a1fe-7650edf5f721
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
1 June 2000
Shugart, Yin Yao
e3183e57-94cf-4009-a1fe-7650edf5f721
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Shugart, Yin Yao and Collins, Andrew
(2000)
Combined segregation and linkage analysis of 59 Hodgkin's disease families indicates the role of HLA determinants.
European Journal of Human Genetics, 8 (6), .
(doi:10.1038/sj.ejhg.5200419).
Abstract
Through a literature search, we identified a total of 59 nuclear families with Hodgkin's disease (HD). The affected individuals in these families were HLA haplotyped. To evaluate the role of HLA-linked determinants of HD and investigate the mode of inheritance of familial HD, a combined segregation and linkage analysis was performed, together with a semi-parametric analysis of sib pairs. Amongst single locus models, a general single locus model showed no improvement over an additive model. However, a two locus additive model gave the best overall fit and a lod score of 3.55. We conclude that HD is most likely to be determined by both an HLA-associated major gene and other non-HLA genetic factors together with environmental effects.
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Published date: 1 June 2000
Keywords:
EBV, HLA, Hodgkin's disease, Linkage, Sib pairs
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Local EPrints ID: 470736
URI: http://eprints.soton.ac.uk/id/eprint/470736
ISSN: 1018-4813
PURE UUID: 2a9f5887-53d5-4fd1-a591-4847f0693c3d
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Date deposited: 19 Oct 2022 16:32
Last modified: 17 Mar 2024 02:37
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Author:
Yin Yao Shugart
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