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The impact of redefining affection status for alcoholism on affected- sib-pair analysis

The impact of redefining affection status for alcoholism on affected- sib-pair analysis
The impact of redefining affection status for alcoholism on affected- sib-pair analysis

The analysis of a complex disease such as alcohol dependence requires a more precise definition of affection status. Collaborative Study on the Genetics of Alcoholism (COGA) provided a variety of qualitative and quantitative measures as well as genotype information, in addition to two criteria of affection status. To identify two groups of phenotypically 'more homogeneous' individuals among alcoholics (COGA criterion), we redefined affection status by using cluster analysis and classification and regression tree, incorporating some important covariates such as event related potentials, monoamine oxidase B activity, status of smoking, age of onset, three variables of personality assessed with the Tridimensional Personality Questionnaire and three latent class variables. With redefined affection status, we repeated nonparametric analysis by three sib pair analysis programs (SIBPAL, SIBPAIR, and BETA) using nine candidate DNA markers identified by Reich et al. [1998] and Long et al. [1998]. The goals of our analysis are 1) to confirm previous results for these nine markers with redefined affection status and 2) to compare the performance from these three programs.

Classification and regression tree, Cluster analysis
0741-0395
S151-S156
Fann, Cathy S.J.
09201ac7-c8ea-41f1-a377-0698ce50c264
Shugart, Yin Y.
df04db1d-db61-48d1-bbe0-09aad3ca8601
Lachman, Herb
7e76636b-d326-424b-a5b1-b7269f284bce
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Chang, C. J.
39f2a55b-fb81-4a6c-a4c8-0229ba731632
Fann, Cathy S.J.
09201ac7-c8ea-41f1-a377-0698ce50c264
Shugart, Yin Y.
df04db1d-db61-48d1-bbe0-09aad3ca8601
Lachman, Herb
7e76636b-d326-424b-a5b1-b7269f284bce
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Chang, C. J.
39f2a55b-fb81-4a6c-a4c8-0229ba731632

Fann, Cathy S.J., Shugart, Yin Y., Lachman, Herb, Collins, Andrew and Chang, C. J. (1999) The impact of redefining affection status for alcoholism on affected- sib-pair analysis. Genetic Epidemiology, 17 (SUPPL. 1), S151-S156. (doi:10.1002/gepi.1370170726).

Record type: Article

Abstract

The analysis of a complex disease such as alcohol dependence requires a more precise definition of affection status. Collaborative Study on the Genetics of Alcoholism (COGA) provided a variety of qualitative and quantitative measures as well as genotype information, in addition to two criteria of affection status. To identify two groups of phenotypically 'more homogeneous' individuals among alcoholics (COGA criterion), we redefined affection status by using cluster analysis and classification and regression tree, incorporating some important covariates such as event related potentials, monoamine oxidase B activity, status of smoking, age of onset, three variables of personality assessed with the Tridimensional Personality Questionnaire and three latent class variables. With redefined affection status, we repeated nonparametric analysis by three sib pair analysis programs (SIBPAL, SIBPAIR, and BETA) using nine candidate DNA markers identified by Reich et al. [1998] and Long et al. [1998]. The goals of our analysis are 1) to confirm previous results for these nine markers with redefined affection status and 2) to compare the performance from these three programs.

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More information

Published date: 1 January 1999
Keywords: Classification and regression tree, Cluster analysis

Identifiers

Local EPrints ID: 470756
URI: http://eprints.soton.ac.uk/id/eprint/470756
ISSN: 0741-0395
PURE UUID: c341f5d5-1f5d-4149-b83d-77b24491f3a5
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771

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Date deposited: 19 Oct 2022 16:57
Last modified: 17 Mar 2024 02:37

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Contributors

Author: Cathy S.J. Fann
Author: Yin Y. Shugart
Author: Herb Lachman
Author: Andrew Collins ORCID iD
Author: C. J. Chang

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