The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria

Accepted/In Press date: 24 September 2022

Published date: 2 October 2022

Additional Information: Full list of authors: Céline Dalle, Jérémy Tournayre, Malwina Mainka, Alicja Basiak-Rasała, Mélanie Pétéra, Sophie Lefèvre-Arbogast, Jessica Dalloux-Chioccioli, Mélanie Deschasaux-Tanguy, Lucie Lécuyer, Emmanuelle Kesse-Guyot, Léopold Fezeu, Serge Hercberg, Pilar Galan, Cécilia Samieri, Katarzyna Zatońska, Philip C. Calder, Mads Fiil Hjorth, Arne Astrup, André Mazur, Justine Bertrand-Michel, Nils H. Schebb, Andrzej Szuba, Mathilde Touvier, John W. Newman and Cécile Gladine Funding Information: National research agencies: (i) French (grant N° ANR-16-HDHL-0004-01/02), (ii) German (BMBF grant N° 01EA1702), (iii) Danish (grant N° 4203-00006B) and (iv) Polish (grant N° ERAH.E220.18.001) in the framework of the Oxygenate project supported by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL). The main PURE study and its components are funded by the Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario and through unrestricted grants from several pharmaceutical companies, Poland substudy: Polish Ministry of Science and Higher Education (grant No. 290/W-PURE/2008/0). And USDA CRIS Project 2032-51530-025-00D. Funding Information: The authors would like to thank Dominique Bayle, Séverine Valéro, Nicole Hartung, Nadja Kampschulte, Elisabeth Koch, Laura Kutzner and Katharina Rund for supporting sample preparation. This study was supported by French, German, Danish and Polish national research agencies (respectively, ANR, grant N° ANR-16-HDHL-0004-01/02; the German Federal Ministry for Education and Research (BMBF), grant N°01EA1702; the Danish Innovation Fonden, grant N° 4203–00006B; and the Polish national center for research and development, grant N° ERAH.E220.18.001) in the framework of the Oxygenate project supported by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL; http://www.healthydietforhealthylife.eu/ ). Independent support was provided by USDA CRIS Project 2032-51530-025-00D to JWN. The USDA is an equal opportunity employer and provider. The authors thank Younes Esseddik, Thi Hong Van Duong, Régis Gatibelza, Jagatjit Mohinder and Aladi Timera (computer scientists); Fabien Szabo de Edelenyi, Julien Allegre, Nathalie Arnault, Laurent Bourhis, Nicolas Dechamp (data-manager/statisticians); Cédric Agaësse, Alexandre De Sa, Rebecca Lutchia (dietitians), Merveille Kouam (health event validator); Maria Gomes (Nutrinaute support); and Nathalie Druesne-Pecollo (operational coordination) for their technical contribution to the NutriNet-Santé study. We thank all the volunteers in the NutriNet-Santé cohort. The NutriNet-Santé study was supported by the following public institutions: Ministère de la Santé, Santé Publique France, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Conservatoire National des Arts et Métiers (CNAM) and Université Sorbonne Paris Nord. Publisher Copyright: © 2022 by the authors.

Keywords: lipid mediators, lipidomics, metabolic phenotyping, metabolic syndrome, oxylipins

Local EPrints ID: 470782

URI: http://eprints.soton.ac.uk/id/eprint/470782

DOI: doi:10.3390/ijms231911688

ISSN: 1422-0067

PURE UUID: 23581691-6aac-4707-97d5-e0156ba8dfb5

ORCID for Philip Calder: orcid.org/0000-0002-6038-710X

Date deposited: 19 Oct 2022 17:10

Last modified: 17 Mar 2024 02:42