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The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria

The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria
The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria
Metabolic syndrome (MetS) is a complex condition encompassing a constellation of cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating many cardiometabolic functions. Plasma oxylipin signature could provide a new clinical tool to enhance the phenotyping of MetS pathophysiology. A high-throughput validated mass spectrometry method, allowing for the quantitative profiling of over 130 oxylipins, was applied to identify and validate the oxylipin signature of MetS in two independent nested case/control studies involving 476 participants. We identified an oxylipin signature of MetS (coined OxyScore), including 23 oxylipins and having high performances in classification and replicability (cross-validated AUCROC of 89%, 95% CI: 85–93% and 78%, 95% CI: 72–85% in the Discovery and Replication studies, respectively). Correlation analysis and comparison with a classification model incorporating the MetS criteria showed that the oxylipin signature brings consistent and complementary information to the clinical criteria. Being linked with the regulation of various biological processes, the candidate oxylipins provide an integrative phenotyping of MetS regarding the activation and/or negative feedback regulation of crucial molecular pathways. This may help identify patients at higher risk of cardiometabolic diseases. The oxylipin signature of patients with metabolic syndrome enhances MetS phenotyping and may ultimately help to better stratify the risk of cardiometabolic diseases.
1422-0067
Dalle, Céline
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Tournayre, Jérémy
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Mainka, Malwina
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Basiak-Rasała,, Alicja
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Pétéra, Mélanie
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Lefèvre-Arbogast, Sophie
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Dalloux-Chioccioli, Jessica
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Deschasaux-Tanguy, Mélanie
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Lécuyer, Lucie
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Kesse-Guyot, Emmanuelle
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Fezeu, Léopold
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Hercberg, Serge
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Galan, Pilar
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Samieri, Cécilia
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Zatońska, Katarzyna
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Calder, Philip
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Hjorth, Mads Fiil
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Astrup, Arne
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Mazur, Andre
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Bertrand-Michael, Justine
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Schebb, Nils Helge
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Szuba, Andrzej
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Touvier, Mathilde
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Newman, John W.
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Gladine, Cécile
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Dalle, Céline
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Tournayre, Jérémy
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Mainka, Malwina
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Basiak-Rasała,, Alicja
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Pétéra, Mélanie
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Lefèvre-Arbogast, Sophie
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Dalloux-Chioccioli, Jessica
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Deschasaux-Tanguy, Mélanie
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Lécuyer, Lucie
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Kesse-Guyot, Emmanuelle
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Fezeu, Léopold
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Hercberg, Serge
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Galan, Pilar
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Samieri, Cécilia
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Zatońska, Katarzyna
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Calder, Philip
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Hjorth, Mads Fiil
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Astrup, Arne
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Mazur, Andre
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Bertrand-Michael, Justine
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Schebb, Nils Helge
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Szuba, Andrzej
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Touvier, Mathilde
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Newman, John W.
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Gladine, Cécile
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Dalle, Céline, Tournayre, Jérémy, Mainka, Malwina, Basiak-Rasała,, Alicja, Pétéra, Mélanie, Lefèvre-Arbogast, Sophie, Dalloux-Chioccioli, Jessica, Deschasaux-Tanguy, Mélanie, Lécuyer, Lucie, Kesse-Guyot, Emmanuelle, Fezeu, Léopold, Hercberg, Serge, Galan, Pilar, Samieri, Cécilia, Zatońska, Katarzyna, Calder, Philip, Hjorth, Mads Fiil, Astrup, Arne, Mazur, Andre, Bertrand-Michael, Justine, Schebb, Nils Helge, Szuba, Andrzej, Touvier, Mathilde, Newman, John W. and Gladine, Cécile (2022) The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria. International Journal of Molecular Sciences. (doi:10.3390/ijms231911688).

Record type: Article

Abstract

Metabolic syndrome (MetS) is a complex condition encompassing a constellation of cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating many cardiometabolic functions. Plasma oxylipin signature could provide a new clinical tool to enhance the phenotyping of MetS pathophysiology. A high-throughput validated mass spectrometry method, allowing for the quantitative profiling of over 130 oxylipins, was applied to identify and validate the oxylipin signature of MetS in two independent nested case/control studies involving 476 participants. We identified an oxylipin signature of MetS (coined OxyScore), including 23 oxylipins and having high performances in classification and replicability (cross-validated AUCROC of 89%, 95% CI: 85–93% and 78%, 95% CI: 72–85% in the Discovery and Replication studies, respectively). Correlation analysis and comparison with a classification model incorporating the MetS criteria showed that the oxylipin signature brings consistent and complementary information to the clinical criteria. Being linked with the regulation of various biological processes, the candidate oxylipins provide an integrative phenotyping of MetS regarding the activation and/or negative feedback regulation of crucial molecular pathways. This may help identify patients at higher risk of cardiometabolic diseases. The oxylipin signature of patients with metabolic syndrome enhances MetS phenotyping and may ultimately help to better stratify the risk of cardiometabolic diseases.

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Accepted/In Press date: 24 September 2022
Published date: 2 October 2022
Additional Information: Full list of authors: Céline Dalle, Jérémy Tournayre, Malwina Mainka, Alicja Basiak-Rasała, Mélanie Pétéra, Sophie Lefèvre-Arbogast, Jessica Dalloux-Chioccioli, Mélanie Deschasaux-Tanguy, Lucie Lécuyer, Emmanuelle Kesse-Guyot, Léopold Fezeu, Serge Hercberg, Pilar Galan, Cécilia Samieri, Katarzyna Zatońska, Philip C. Calder, Mads Fiil Hjorth, Arne Astrup, André Mazur, Justine Bertrand-Michel, Nils H. Schebb, Andrzej Szuba, Mathilde Touvier, John W. Newman and Cécile Gladine

Identifiers

Local EPrints ID: 470782
URI: http://eprints.soton.ac.uk/id/eprint/470782
ISSN: 1422-0067
PURE UUID: 23581691-6aac-4707-97d5-e0156ba8dfb5
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 19 Oct 2022 17:10
Last modified: 20 Oct 2022 01:34

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Contributors

Author: Céline Dalle
Author: Jérémy Tournayre
Author: Malwina Mainka
Author: Alicja Basiak-Rasała,
Author: Mélanie Pétéra
Author: Sophie Lefèvre-Arbogast
Author: Jessica Dalloux-Chioccioli
Author: Mélanie Deschasaux-Tanguy
Author: Lucie Lécuyer
Author: Emmanuelle Kesse-Guyot
Author: Léopold Fezeu
Author: Serge Hercberg
Author: Pilar Galan
Author: Cécilia Samieri
Author: Katarzyna Zatońska
Author: Philip Calder ORCID iD
Author: Mads Fiil Hjorth
Author: Arne Astrup
Author: Andre Mazur
Author: Justine Bertrand-Michael
Author: Nils Helge Schebb
Author: Andrzej Szuba
Author: Mathilde Touvier
Author: John W. Newman
Author: Cécile Gladine

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