Hardy-Weinberg quality control
Hardy-Weinberg quality control
An efficient test of deviation from Hardy-Weinberg frequencies with one degree of freedom was applied to 44 marker loci in a genome scan, and 7 loci had a significant excess of apparent homozygotes (χ2((1)) > 6) suggestive of typing error. In this example evidence for linkage did not increase when outliers were censored. Statistical quality control is an essential part of genotyping, and the effect of mistyping and map error should be considered in evaluating any genome scan.
535-538
Gomes, I.
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Collins, A.
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Lonjou, C.
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Thomas, N. S.
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Wilkinson, J.
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Watson, M.
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Morton, N.
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1 November 1999
Gomes, I.
36879969-b285-44d2-9140-8ef7c97866f1
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Lonjou, C.
2dfae8d7-8a9c-4a2e-84ed-7ae1a5318f7e
Thomas, N. S.
bfe39cd3-60b9-4733-8921-db53f7851e4c
Wilkinson, J.
0af49238-dc2c-43bc-a9aa-6d98038bf0ad
Watson, M.
733991bd-55dc-4237-9a0e-d906cd617dd8
Morton, N.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Gomes, I., Collins, A., Lonjou, C., Thomas, N. S., Wilkinson, J., Watson, M. and Morton, N.
(1999)
Hardy-Weinberg quality control.
Annals of Human Genetics, 63 (6), .
(doi:10.1017/S0003480099007824).
Abstract
An efficient test of deviation from Hardy-Weinberg frequencies with one degree of freedom was applied to 44 marker loci in a genome scan, and 7 loci had a significant excess of apparent homozygotes (χ2((1)) > 6) suggestive of typing error. In this example evidence for linkage did not increase when outliers were censored. Statistical quality control is an essential part of genotyping, and the effect of mistyping and map error should be considered in evaluating any genome scan.
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Published date: 1 November 1999
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Local EPrints ID: 470885
URI: http://eprints.soton.ac.uk/id/eprint/470885
ISSN: 0003-4800
PURE UUID: fce32fcd-9795-4989-9c26-724a30d78eb8
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Date deposited: 20 Oct 2022 16:45
Last modified: 17 Mar 2024 02:37
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Contributors
Author:
I. Gomes
Author:
C. Lonjou
Author:
N. S. Thomas
Author:
J. Wilkinson
Author:
M. Watson
Author:
N. Morton
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