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Allelic association under map error and recombinational heterogeneity: A tale of two sites

Allelic association under map error and recombinational heterogeneity: A tale of two sites
Allelic association under map error and recombinational heterogeneity: A tale of two sites

Recombination acts on the genetic map, not on the physical map. On the other hand, the physical map is usually more accurate. Choice of the genetic or physical map for positional cloning by allelic association depends on the goodness of fit of data to each map under an established model. Huntington disease illustrates the usual case in which the greater reliability of physical data outweighs recombinational heterogeneity. Hemochromatosis represents an exceptional case in which unrecognized recombinational heterogeneity retarded positional cloning for a decade. The Malecot model performs well for major genes, but no approach assuming either equilibrium or disequilibrium has been validated for oligogenes contributing to common disease. In this case of greatest interest, the power of allelic association relative to linkage is less clear than for major genes.

Disease gene mapping, Hemochromatosis, Huntington disease, Malecot model
0027-8424
11366-11370
Lonjou, Christine
bb6ed94a-0ab0-4cf5-92f9-ba681713a952
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Ajioka, Richard S.
ebf98373-cb6a-4652-880c-722b8e0323ab
Jorde, Lynn B.
cfa00979-fa9c-4d88-bb67-6092ef353b86
Kushner, James P.
904820fd-65e4-4eab-a6f7-e6053454545f
Morton, Newton E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Lonjou, Christine
bb6ed94a-0ab0-4cf5-92f9-ba681713a952
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Ajioka, Richard S.
ebf98373-cb6a-4652-880c-722b8e0323ab
Jorde, Lynn B.
cfa00979-fa9c-4d88-bb67-6092ef353b86
Kushner, James P.
904820fd-65e4-4eab-a6f7-e6053454545f
Morton, Newton E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7

Lonjou, Christine, Collins, Andrew, Ajioka, Richard S., Jorde, Lynn B., Kushner, James P. and Morton, Newton E. (1998) Allelic association under map error and recombinational heterogeneity: A tale of two sites. Proceedings of the National Academy of Sciences, 95 (19), 11366-11370. (doi:10.1073/pnas.95.19.11366).

Record type: Article

Abstract

Recombination acts on the genetic map, not on the physical map. On the other hand, the physical map is usually more accurate. Choice of the genetic or physical map for positional cloning by allelic association depends on the goodness of fit of data to each map under an established model. Huntington disease illustrates the usual case in which the greater reliability of physical data outweighs recombinational heterogeneity. Hemochromatosis represents an exceptional case in which unrecognized recombinational heterogeneity retarded positional cloning for a decade. The Malecot model performs well for major genes, but no approach assuming either equilibrium or disequilibrium has been validated for oligogenes contributing to common disease. In this case of greatest interest, the power of allelic association relative to linkage is less clear than for major genes.

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More information

Published date: 15 September 1998
Keywords: Disease gene mapping, Hemochromatosis, Huntington disease, Malecot model

Identifiers

Local EPrints ID: 470889
URI: http://eprints.soton.ac.uk/id/eprint/470889
ISSN: 0027-8424
PURE UUID: 9f9df62d-21e8-43dd-834d-d8fdf9ce9b36
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771

Catalogue record

Date deposited: 20 Oct 2022 16:46
Last modified: 21 Oct 2022 01:32

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Contributors

Author: Christine Lonjou
Author: Andrew Collins ORCID iD
Author: Richard S. Ajioka
Author: Lynn B. Jorde
Author: James P. Kushner
Author: Newton E. Morton

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