Allelic association between marker loci
Allelic association between marker loci
Allelic association has proven useful to refine the location of major genes prior to positional cloning, but it is of uncertain value for genome scans in complex inheritance. We have extended kinship theory to give information content for linkage and allelic association. Application to pairs of closely linked markers as a surrogate for marker x oligogene pairs indicates that association is largely determined by regional founders, with little effect of subsequent demography. Sub-Saharan Africa has the least allelic association, consistent with settlement of other regions by small numbers of founders. Recent speculation about substantial advantages of isolates over large populations, of constant size over expansion, and of F1 hybrids over incrosses is not supported by theory or data. On the contrary, fewer affected cases, less opportunity for replication, and more stochastic variation tend to make isolates less informative for allelic association, as they are for linkage.
Disease mapping, Kinship, Linkage disequilibrium, Population structure, Positional cloning
1621-1626
Lonjou, C.
2dfae8d7-8a9c-4a2e-84ed-7ae1a5318f7e
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Morton, N. E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
16 February 1999
Lonjou, C.
2dfae8d7-8a9c-4a2e-84ed-7ae1a5318f7e
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Morton, N. E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Lonjou, C., Collins, A. and Morton, N. E.
(1999)
Allelic association between marker loci.
Proceedings of the National Academy of Sciences, 96 (4), .
(doi:10.1073/pnas.96.4.1621).
Abstract
Allelic association has proven useful to refine the location of major genes prior to positional cloning, but it is of uncertain value for genome scans in complex inheritance. We have extended kinship theory to give information content for linkage and allelic association. Application to pairs of closely linked markers as a surrogate for marker x oligogene pairs indicates that association is largely determined by regional founders, with little effect of subsequent demography. Sub-Saharan Africa has the least allelic association, consistent with settlement of other regions by small numbers of founders. Recent speculation about substantial advantages of isolates over large populations, of constant size over expansion, and of F1 hybrids over incrosses is not supported by theory or data. On the contrary, fewer affected cases, less opportunity for replication, and more stochastic variation tend to make isolates less informative for allelic association, as they are for linkage.
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Published date: 16 February 1999
Keywords:
Disease mapping, Kinship, Linkage disequilibrium, Population structure, Positional cloning
Identifiers
Local EPrints ID: 470926
URI: http://eprints.soton.ac.uk/id/eprint/470926
ISSN: 0027-8424
PURE UUID: bb982bed-e83f-4cc8-b28b-c090a8f3f301
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Date deposited: 21 Oct 2022 16:33
Last modified: 17 Mar 2024 02:37
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Contributors
Author:
C. Lonjou
Author:
N. E. Morton
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