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Limb girdle muscular dystrophy type 2A (CAPN3): Mapping using allelic association

Limb girdle muscular dystrophy type 2A (CAPN3): Mapping using allelic association
Limb girdle muscular dystrophy type 2A (CAPN3): Mapping using allelic association

Recently a graphical study of linkage disequilibrium around the CAPN3 locus failed to refine the 1.3-Mb interval suggested by haplotype sharing. On the contrary, the Malecot model as implemented in the ALLASS program maps CAPN3 within 3 kb of its true location (23 kb from the locus midpoint), overcoming identified problems with small samples, interrelated sibships, and short duration.

Gene mapping, Linkage disequilibrium, Malecot model
0001-5652
333-337
Lonjou, Christine
bb6ed94a-0ab0-4cf5-92f9-ba681713a952
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Beckmann, Jacques
3880c216-3f63-4b08-bf61-8542ebcf680d
Allamand, Valérie
36117e89-ec38-45f2-9210-8c386a1db98a
Morton, Newton
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Lonjou, Christine
bb6ed94a-0ab0-4cf5-92f9-ba681713a952
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Beckmann, Jacques
3880c216-3f63-4b08-bf61-8542ebcf680d
Allamand, Valérie
36117e89-ec38-45f2-9210-8c386a1db98a
Morton, Newton
c668e2be-074a-4a0a-a2ca-e8f51830ebb7

Lonjou, Christine, Collins, Andrew, Beckmann, Jacques, Allamand, Valérie and Morton, Newton (1998) Limb girdle muscular dystrophy type 2A (CAPN3): Mapping using allelic association. Human Heredity, 48 (6), 333-337. (doi:10.1159/000022825).

Record type: Article

Abstract

Recently a graphical study of linkage disequilibrium around the CAPN3 locus failed to refine the 1.3-Mb interval suggested by haplotype sharing. On the contrary, the Malecot model as implemented in the ALLASS program maps CAPN3 within 3 kb of its true location (23 kb from the locus midpoint), overcoming identified problems with small samples, interrelated sibships, and short duration.

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More information

Published date: November 1998
Keywords: Gene mapping, Linkage disequilibrium, Malecot model

Identifiers

Local EPrints ID: 470931
URI: http://eprints.soton.ac.uk/id/eprint/470931
DOI: doi:10.1159/000022825
ISSN: 0001-5652
PURE UUID: 58242cc4-933d-4fa1-a4b7-4e6106a3936f
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771

Catalogue record

Date deposited: 21 Oct 2022 16:33
Last modified: 17 Mar 2024 02:37

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Contributors

Author: Christine Lonjou
Author: Andrew Collins ORCID iD
Author: Jacques Beckmann
Author: Valérie Allamand
Author: Newton Morton

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