Exclusion from proximal 11q of a common gene with megaphenic effect on atopy
Exclusion from proximal 11q of a common gene with megaphenic effect on atopy
We have typed three markers on proximal 11q in 131 random families with three or more children studied for atopy. A summary map that includes the FCER1B candidate was constructed. Using a 2‐locus disease model, we performed combined segregation and linkage analysis of three models, none of which suggested linkage. Nine marker loci on other chromosomes were also negative. In the regions swept by these 12 markers we cannot rule out a rare gene, perhaps of large effect, nor a common gene of small effect. However, a common gene of large effect is excluded. These results and alternative strategies are discussed in the perspective of inconsistent evidence for a major atopy gene.
403-411
WATSON, M.
731c1851-69b8-4fb3-a210-cf1be9e77041
LAWRENCE, S.
7d8ad1ee-4204-4e03-a516-0dc0c7363212
COLLINS, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
BEASLEY, R.
56d72343-bd56-4426-a570-b47e513fc4ab
DOULL, I.
1729256e-e13f-4ce6-a877-e5a5fa50f37a
BEGISHVILI, B.
f6067301-0bae-4eab-ba97-6a44dc1c955c
LAMPE, F.
90b9125d-0f6f-4f07-b774-3325e6c5135e
HOLGATE, S. T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
MORTON, N. E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
1 October 1995
WATSON, M.
731c1851-69b8-4fb3-a210-cf1be9e77041
LAWRENCE, S.
7d8ad1ee-4204-4e03-a516-0dc0c7363212
COLLINS, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
BEASLEY, R.
56d72343-bd56-4426-a570-b47e513fc4ab
DOULL, I.
1729256e-e13f-4ce6-a877-e5a5fa50f37a
BEGISHVILI, B.
f6067301-0bae-4eab-ba97-6a44dc1c955c
LAMPE, F.
90b9125d-0f6f-4f07-b774-3325e6c5135e
HOLGATE, S. T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
MORTON, N. E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
WATSON, M., LAWRENCE, S., COLLINS, A., BEASLEY, R., DOULL, I., BEGISHVILI, B., LAMPE, F., HOLGATE, S. T. and MORTON, N. E.
(1995)
Exclusion from proximal 11q of a common gene with megaphenic effect on atopy.
Annals of Human Genetics, 59 (4), .
(doi:10.1111/j.1469-1809.1995.tb00759.x).
Abstract
We have typed three markers on proximal 11q in 131 random families with three or more children studied for atopy. A summary map that includes the FCER1B candidate was constructed. Using a 2‐locus disease model, we performed combined segregation and linkage analysis of three models, none of which suggested linkage. Nine marker loci on other chromosomes were also negative. In the regions swept by these 12 markers we cannot rule out a rare gene, perhaps of large effect, nor a common gene of small effect. However, a common gene of large effect is excluded. These results and alternative strategies are discussed in the perspective of inconsistent evidence for a major atopy gene.
This record has no associated files available for download.
More information
Published date: 1 October 1995
Identifiers
Local EPrints ID: 470936
URI: http://eprints.soton.ac.uk/id/eprint/470936
ISSN: 0003-4800
PURE UUID: e61a4af3-74a1-4661-8ac7-f9a38650e55f
Catalogue record
Date deposited: 21 Oct 2022 16:34
Last modified: 17 Mar 2024 02:38
Export record
Altmetrics
Contributors
Author:
M. WATSON
Author:
S. LAWRENCE
Author:
R. BEASLEY
Author:
I. DOULL
Author:
B. BEGISHVILI
Author:
F. LAMPE
Author:
N. E. MORTON
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
