Mapping disease genes using the Malecot model for allelic association and the beta model for linkage
Mapping disease genes using the Malecot model for allelic association and the beta model for linkage
Although there are a number of alternative methods for mapping oligogenes the beta model implemented in the program BETA has been shown to be amongst the more powerful. The model has been applied to a sample of 240 asthma and atopy families typed for markers on chromosome 12 and the results suggest at least one asthma determinant may be present. The Malecot model implemented in the program ALLASS has yet to be applied to oligogenes but has been effective in the localization of major genes by exploiting the relationship between linkage disequilibrium and distance from the gene. Extension to oligogenes would seem to be a profitable way forward.
53-56
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
1 December 1999
Collins, A.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Collins, A.
(1999)
Mapping disease genes using the Malecot model for allelic association and the beta model for linkage.
Clinical and Experimental Allergy, 29 (Suppl4), .
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Abstract
Although there are a number of alternative methods for mapping oligogenes the beta model implemented in the program BETA has been shown to be amongst the more powerful. The model has been applied to a sample of 240 asthma and atopy families typed for markers on chromosome 12 and the results suggest at least one asthma determinant may be present. The Malecot model implemented in the program ALLASS has yet to be applied to oligogenes but has been effective in the localization of major genes by exploiting the relationship between linkage disequilibrium and distance from the gene. Extension to oligogenes would seem to be a profitable way forward.
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Published date: 1 December 1999
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Local EPrints ID: 470954
URI: http://eprints.soton.ac.uk/id/eprint/470954
ISSN: 0954-7894
PURE UUID: 7209e7c3-dffd-4223-b1c7-6057d3822459
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Date deposited: 21 Oct 2022 16:39
Last modified: 22 Oct 2022 01:32
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