A metric map of humans: 23,500 loci in 850 bands
A metric map of humans: 23,500 loci in 850 bands
High-resolution maps integrated with the enhanced location data base software (ldb+) give improved estimates of genetic parameters and reveal characteristics of cytogenetic bands. Chiasma interference is intermediate between Kosambi and Carter–Falconer levels, as in Drosophila and the mouse. The autosomal genetic map is 2832 and 4348 centimorgans in males and females, respectively. Telomeric T-bands are strikingly associated with male recombination and gene density. Position and centromeric heterochromatin have large effects, but nontelomeric R-bands are not significantly different from G-bands. Several possible reasons are discussed. These regularities validate the maps, despite their high resolution and inevitable local errors. No other approach has been demonstrated to integrate such a large number of loci, which are increasing at about 45% per year. The maps and the data and …
map integration, cytogenetic band
14771-14775
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
10 December 1996
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Collins, Andrew
(1996)
A metric map of humans: 23,500 loci in 850 bands.
Proceedings of the National Academy of Sciences of the United States of America, 93 (25), .
(doi:10.1073/pnas.93.25.14771).
Abstract
High-resolution maps integrated with the enhanced location data base software (ldb+) give improved estimates of genetic parameters and reveal characteristics of cytogenetic bands. Chiasma interference is intermediate between Kosambi and Carter–Falconer levels, as in Drosophila and the mouse. The autosomal genetic map is 2832 and 4348 centimorgans in males and females, respectively. Telomeric T-bands are strikingly associated with male recombination and gene density. Position and centromeric heterochromatin have large effects, but nontelomeric R-bands are not significantly different from G-bands. Several possible reasons are discussed. These regularities validate the maps, despite their high resolution and inevitable local errors. No other approach has been demonstrated to integrate such a large number of loci, which are increasing at about 45% per year. The maps and the data and …
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Published date: 10 December 1996
Additional Information:
Maps and data at:
http://cedar.genetics.soton.ac.uk/public_html
Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences
Keywords:
map integration, cytogenetic band
Identifiers
Local EPrints ID: 471070
URI: http://eprints.soton.ac.uk/id/eprint/471070
ISSN: 0027-8424
PURE UUID: 0bf6d7fb-f7a2-4222-9272-5c7f31e9488e
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Date deposited: 25 Oct 2022 16:40
Last modified: 17 Mar 2024 02:38
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