Oral spironolactone for acne vulgaris in adult females: an update of the literature

Barker, Ruth, Wilcox, Christopher and Layton, Alison M. (2020) Oral spironolactone for acne vulgaris in adult females: an update of the literature. American Journal of Clinical Dermatology, 21 (2), 303–305. (doi:10.1007/s40257-020-00511-5).

Abstract

Dear Editor,In 2016, the article Oral Spironolactone for Acne Vulgaris inAdult Females: A Hybrid Systematic Review, was publishedin your journal [1]. This article considered all available dataon spironolactone for acne in adult females, and concludedthat the quality of research was not of a high enough standard to guide prescribing recommendations. Spironolactonetherefore continues to be prescribed of license in the treatment of acne, based on case reports and expert opinionrather than robust evidence.An updated search of the literature, using the same searchstrategy as the original review, was performed on 5 February, 2020 to identify any new published data in the feld.Electronic searches were conducted on EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials,Cochrane Skin, Science Citation Index and LILACS databases. Trial databases searched included the meta Registerof Controlled Trials, US National Institutes of Health ongoing trials register, ANZCTR, World Health Organizationand the European Union’s clinical trials register. Finally, aGoogle hand search was performed using the search termsacne and spironolactone

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