Location, location, location: nuclear structure regulates gene expression in neurons.
Location, location, location: nuclear structure regulates gene expression in neurons.
Genome architecture plays a critical role in regulating the expression of genes that are essential for nervous system development. During neuronal differentiation, spatially and temporally regulated transcription allows neuronal migration, the growth of dendrites and axons, and at later stages, synaptic formation and the establishment of neuronal circuitry. Genome topology and relocation of gene loci within the nucleus are now regarded as key factors that contribute to transcriptional regulation. Here, we review recent work supporting the hypothesis that the dynamic organization of chromatin within the nucleus impacts gene activation in response to extrinsic signalling and during neuronal differentiation. The consequences of disruption of the genome architecture on neuronal health will be also discussed.
16-25
Brookes, Emily
425dafc2-111b-4f6c-9336-f720c4ef8cac
Riccio, Antonella
4fee45ce-4e1c-474c-a24d-fa190fbc314d
December 2019
Brookes, Emily
425dafc2-111b-4f6c-9336-f720c4ef8cac
Riccio, Antonella
4fee45ce-4e1c-474c-a24d-fa190fbc314d
Brookes, Emily and Riccio, Antonella
(2019)
Location, location, location: nuclear structure regulates gene expression in neurons.
Current opinion in neurobiology, 59, .
(doi:10.1016/j.conb.2019.03.009).
Abstract
Genome architecture plays a critical role in regulating the expression of genes that are essential for nervous system development. During neuronal differentiation, spatially and temporally regulated transcription allows neuronal migration, the growth of dendrites and axons, and at later stages, synaptic formation and the establishment of neuronal circuitry. Genome topology and relocation of gene loci within the nucleus are now regarded as key factors that contribute to transcriptional regulation. Here, we review recent work supporting the hypothesis that the dynamic organization of chromatin within the nucleus impacts gene activation in response to extrinsic signalling and during neuronal differentiation. The consequences of disruption of the genome architecture on neuronal health will be also discussed.
This record has no associated files available for download.
More information
e-pub ahead of print date: 18 April 2019
Published date: December 2019
Identifiers
Local EPrints ID: 471256
URI: http://eprints.soton.ac.uk/id/eprint/471256
ISSN: 0959-4388
PURE UUID: b1c57481-f941-446a-a056-b14a4a90a9ff
Catalogue record
Date deposited: 01 Nov 2022 17:43
Last modified: 17 Mar 2024 04:14
Export record
Altmetrics
Contributors
Author:
Emily Brookes
Author:
Antonella Riccio
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics