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THz spectroscopy of BSA in a surface-tension confined flow-cell

THz spectroscopy of BSA in a surface-tension confined flow-cell
THz spectroscopy of BSA in a surface-tension confined flow-cell

A novel combination of oxygen plasma treatments and machining was used to modify the surface wetting of polytetrafluorethylene (PTFE) to develop a terahertz compatible microfluidic flow-cell that confines aqueous samples with surface tension forces. By increasing the wettability of the water channel and creating superhydrophobic nanostructures on the surrounding substrate, a stark contrast in contact angles was produced that leads to the principle confinement effect. Terahertz time-domain spectroscopy (THz-TDS) was performed on a range of bovine serum albumin (BSA) concentrations, demonstrating the potential for using this chemically inert, bio-compatible material for investigating protein hydration dynamics with THz spectroscopy.

2162-2027
IEEE
Klokkou, Nicholas T.
28e68acd-c66f-495f-87f3-91235fe03503
Rowe, David J.
a0e0fe82-5e29-42b8-b370-5236a722f015
Bowden, Bethany M.
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Sessions, Neil P.
ee737092-56b4-403e-a2f9-764e07e42625
West, Jonathan J.
f1c2e060-16c3-44c0-af70-242a1c58b968
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Apostolopoulos, Vasilis
8a898740-4c71-4040-a577-9b9d70530b4d
Klokkou, Nicholas T.
28e68acd-c66f-495f-87f3-91235fe03503
Rowe, David J.
a0e0fe82-5e29-42b8-b370-5236a722f015
Bowden, Bethany M.
084eeee9-0c23-4d40-ab63-afd7574711fb
Sessions, Neil P.
ee737092-56b4-403e-a2f9-764e07e42625
West, Jonathan J.
f1c2e060-16c3-44c0-af70-242a1c58b968
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Apostolopoulos, Vasilis
8a898740-4c71-4040-a577-9b9d70530b4d

Klokkou, Nicholas T., Rowe, David J., Bowden, Bethany M., Sessions, Neil P., West, Jonathan J., Wilkinson, James S. and Apostolopoulos, Vasilis (2021) THz spectroscopy of BSA in a surface-tension confined flow-cell. In 46th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2021. vol. 2021-August, IEEE.. (doi:10.1109/IRMMW-THz50926.2021.9567508).

Record type: Conference or Workshop Item (Paper)

Abstract

A novel combination of oxygen plasma treatments and machining was used to modify the surface wetting of polytetrafluorethylene (PTFE) to develop a terahertz compatible microfluidic flow-cell that confines aqueous samples with surface tension forces. By increasing the wettability of the water channel and creating superhydrophobic nanostructures on the surrounding substrate, a stark contrast in contact angles was produced that leads to the principle confinement effect. Terahertz time-domain spectroscopy (THz-TDS) was performed on a range of bovine serum albumin (BSA) concentrations, demonstrating the potential for using this chemically inert, bio-compatible material for investigating protein hydration dynamics with THz spectroscopy.

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More information

Published date: 3 September 2021
Venue - Dates: 46th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2021, , Chengdu, China, 2021-08-30 - 2021-09-03

Identifiers

Local EPrints ID: 471380
URI: http://eprints.soton.ac.uk/id/eprint/471380
ISSN: 2162-2027
PURE UUID: 6e40216d-63df-4bc6-9702-d756d5c6adbd
ORCID for Nicholas T. Klokkou: ORCID iD orcid.org/0000-0002-0999-3745
ORCID for David J. Rowe: ORCID iD orcid.org/0000-0002-1167-150X
ORCID for Jonathan J. West: ORCID iD orcid.org/0000-0002-5709-6790
ORCID for James S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697
ORCID for Vasilis Apostolopoulos: ORCID iD orcid.org/0000-0003-3733-2191

Catalogue record

Date deposited: 04 Nov 2022 17:36
Last modified: 17 Mar 2024 04:12

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Contributors

Author: David J. Rowe ORCID iD
Author: Bethany M. Bowden
Author: Neil P. Sessions

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