Heterogeneity of white adipocytes in metabolic disease
Heterogeneity of white adipocytes in metabolic disease
Purpose of review: this review aims to discuss the most recent evidence identifying the presence of distinct white adipocyte subpopulations in white adipose tissue (WAT) and how these may be altered with increasing adiposity and/or metabolic disease. We conceptualise how changes in adipocyte subpopulations may contribute to alterations in WAT function and the development of metabolic diseases such as type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD).
Recent findings: studies utilising novel analytical approaches support the existence of distinct white adipocyte subpopulations in both human and murine WAT. Adipocyte subtypes are potentially functionally distinct and may have different roles in WAT function and obesity-associated metabolic diseases.
Summary: the exploration of white adipocyte heterogeneity using novel analytical technologies, has unveiled a new layer of complexity in the study of WAT biology. Interrogation of potential functional differences between adipocyte subpopulations and their role in the function of different WAT depots is now needed. Through understanding the mechanisms regulating white adipocyte subtype development and potential pathophysiological consequences of changes in the presence of adipocyte subpopulations, studies could provide novel therapeutic targets for the treatment of T2DM, NAFLD and CVD.
adiposity, metabolic disease, snRNA sequencing, white adipocyte
72-77
Bilson, Josh
a99f9320-335c-47c8-bf30-07df48a5467d
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
1 March 2023
Bilson, Josh
a99f9320-335c-47c8-bf30-07df48a5467d
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Bilson, Josh, Sethi, Jaswinder K. and Byrne, Christopher
(2023)
Heterogeneity of white adipocytes in metabolic disease.
Current Opinion in Clinical Nutrition and Metabolic Care, 26 (2), .
(doi:10.1097/MCO.0000000000000885).
Abstract
Purpose of review: this review aims to discuss the most recent evidence identifying the presence of distinct white adipocyte subpopulations in white adipose tissue (WAT) and how these may be altered with increasing adiposity and/or metabolic disease. We conceptualise how changes in adipocyte subpopulations may contribute to alterations in WAT function and the development of metabolic diseases such as type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD).
Recent findings: studies utilising novel analytical approaches support the existence of distinct white adipocyte subpopulations in both human and murine WAT. Adipocyte subtypes are potentially functionally distinct and may have different roles in WAT function and obesity-associated metabolic diseases.
Summary: the exploration of white adipocyte heterogeneity using novel analytical technologies, has unveiled a new layer of complexity in the study of WAT biology. Interrogation of potential functional differences between adipocyte subpopulations and their role in the function of different WAT depots is now needed. Through understanding the mechanisms regulating white adipocyte subtype development and potential pathophysiological consequences of changes in the presence of adipocyte subpopulations, studies could provide novel therapeutic targets for the treatment of T2DM, NAFLD and CVD.
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Accepted/In Press date: 11 October 2022
e-pub ahead of print date: 12 January 2023
Published date: 1 March 2023
Additional Information:
Funding Information:
J.B., J.K.S., and C.D.B. are supported by the National Institute for Health and Care Research through the NIHR Southampton Biomedical Research Centre (Grant Number IS-BRC-20004). This research was funded in part by the Wellcome Trust (Grant number 206453/Z/17/Z to J.K.S.).
Funding Information:
Acknowledgements None. Financial support and sponsorship J.B., J.K.S., and C.D.B. are supported by the National Institute for Health and Care Research through the NIHR Southampton Biomedical ResearchCentre (GrantNumber IS-BRC-20004). This research was funded in part by the WellcomeTrust(Grantnumber206453/Z/17/ZtoJ.K.S.).
Publisher Copyright:
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
Keywords:
adiposity, metabolic disease, snRNA sequencing, white adipocyte
Identifiers
Local EPrints ID: 471440
URI: http://eprints.soton.ac.uk/id/eprint/471440
ISSN: 1363-1950
PURE UUID: 86058d93-4f2f-4ae8-8009-a0401ec76685
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Date deposited: 08 Nov 2022 18:24
Last modified: 12 Nov 2024 05:07
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Author:
Josh Bilson
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