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Heterogeneity of white adipocytes in metabolic disease

Heterogeneity of white adipocytes in metabolic disease
Heterogeneity of white adipocytes in metabolic disease
Purpose of review: this review aims to discuss the most recent evidence identifying the presence of distinct white adipocyte subpopulations in white adipose tissue (WAT) and how these may be altered with increasing adiposity and/or metabolic disease. We conceptualise how changes in adipocyte subpopulations may contribute to alterations in WAT function and the development of metabolic diseases such as type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD).

Recent findings: studies utilising novel analytical approaches support the existence of distinct white adipocyte subpopulations in both human and murine WAT. Adipocyte subtypes are potentially functionally distinct and may have different roles in WAT function and obesity-associated metabolic diseases.

Summary: the exploration of white adipocyte heterogeneity using novel analytical technologies, has unveiled a new layer of complexity in the study of WAT biology. Interrogation of potential functional differences between adipocyte subpopulations and their role in the function of different WAT depots is now needed. Through understanding the mechanisms regulating white adipocyte subtype development and potential pathophysiological consequences of changes in the presence of adipocyte subpopulations, studies could provide novel therapeutic targets for the treatment of T2DM, NAFLD and CVD.


1363-1950
Bilson, Josh
1132faa9-9276-48c7-8d44-ad38dbf1a63a
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Bilson, Josh
1132faa9-9276-48c7-8d44-ad38dbf1a63a
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c

Bilson, Josh, Sethi, Jaswinder K. and Byrne, Christopher (2023) Heterogeneity of white adipocytes in metabolic disease. Current Opinion in Clinical Nutrition and Metabolic Care.

Record type: Review

Abstract

Purpose of review: this review aims to discuss the most recent evidence identifying the presence of distinct white adipocyte subpopulations in white adipose tissue (WAT) and how these may be altered with increasing adiposity and/or metabolic disease. We conceptualise how changes in adipocyte subpopulations may contribute to alterations in WAT function and the development of metabolic diseases such as type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD).

Recent findings: studies utilising novel analytical approaches support the existence of distinct white adipocyte subpopulations in both human and murine WAT. Adipocyte subtypes are potentially functionally distinct and may have different roles in WAT function and obesity-associated metabolic diseases.

Summary: the exploration of white adipocyte heterogeneity using novel analytical technologies, has unveiled a new layer of complexity in the study of WAT biology. Interrogation of potential functional differences between adipocyte subpopulations and their role in the function of different WAT depots is now needed. Through understanding the mechanisms regulating white adipocyte subtype development and potential pathophysiological consequences of changes in the presence of adipocyte subpopulations, studies could provide novel therapeutic targets for the treatment of T2DM, NAFLD and CVD.


Text
20221011_CurrentOpin_AdipocyteSubtypes_Revised - Accepted Manuscript
Restricted to Repository staff only until 11 October 2023.
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HQ_Figure1_JB - Accepted Manuscript
Restricted to Repository staff only
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More information

Accepted/In Press date: 11 October 2022
e-pub ahead of print date: 12 January 2023

Identifiers

Local EPrints ID: 471440
URI: http://eprints.soton.ac.uk/id/eprint/471440
ISSN: 1363-1950
PURE UUID: 86058d93-4f2f-4ae8-8009-a0401ec76685
ORCID for Josh Bilson: ORCID iD orcid.org/0000-0003-4665-3886
ORCID for Jaswinder K. Sethi: ORCID iD orcid.org/0000-0003-4157-0475
ORCID for Christopher Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 08 Nov 2022 18:24
Last modified: 31 Jan 2023 03:00

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Contributors

Author: Josh Bilson ORCID iD

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