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Role of Vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group

Role of Vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group
Role of Vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group
Vitamin D is a key component for optimal growth and for calcium–phosphate homeostasis. Skin photosynthesis is the main source of vitamin D. Limited sun exposure and insufficient dietary vitamin D supply justify vitamin D supplementation in certain age groups. In older adults, recommended doses for vitamin D supplementation vary between 200 and 2000 IU/day, to achieve a goal of circulating 25-hydroxyvitamin D (calcifediol) of at least 50 nmol/L. The target level depends on the population being supplemented, the assessed system, and the outcome. Several recent large randomized trials with oral vitamin D regimens varying between 2000 and 100,000 IU/month and mostly conducted in vitamin D-replete and healthy individuals have failed to detect any efficacy of these approaches for the prevention of fracture and falls. Considering the well-recognized major musculoskeletal disorders associated with severe vitamin D deficiency and taking into account a possible biphasic effects of vitamin D on fracture and fall risks, an European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group convened, carefully reviewed, and analyzed the meta-analyses of randomized controlled trials on the effects of vitamin D on fracture risk, falls or osteoarthritis, and came to the conclusion that 1000 IU daily should be recommended in patients at increased risk of vitamin D deficiency. The group also addressed the identification of patients possibly benefitting from a vitamin D loading dose to achieve early 25-hydroxyvitamin D therapeutic level or from calcifediol administration.
Falls, Fragility fracture, Osteoarthritis, Vitamin D
1594-0667
Chevalley, Thierry
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Brandi, M.L.
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Cashman, Kevin D.
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Cavalier, Etienne
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Harvey, Nicholas
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Maggi, Stefania
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Cooper, Cyrus
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Al-Daghri, Nasser M.
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Bock, Oliver
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Bruyère, Olivier
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Rosa, Mario M.
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Cortet, B.
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Cruz-Jentoft, Alfonso Jose
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Cherubini, Antonio
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Dawson-Hughes, Bess
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Fielding, Roger A.
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Fuggle, Nicholas
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Halbout, Philippe
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Kanis, John A.
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Kaufman, J.M.
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Lamy, Olivier
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Laslop, Andrea
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Prieto Yerro, María Concepción
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Rademecker, Regis Pierre
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Thiyagarajan, Jotheeswaran Amuthavalli
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Thomas, Thierry
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Veronese, Nicola
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de Wit, Marten
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Reginster, Jean Yves
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Rizzoli, Rene
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Chevalley, Thierry
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Brandi, M.L.
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Cashman, Kevin D.
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Cavalier, Etienne
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Harvey, Nicholas
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Maggi, Stefania
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Cooper, Cyrus
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Al-Daghri, Nasser M.
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Bock, Oliver
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Bruyère, Olivier
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Rosa, Mario M.
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Cortet, B.
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Cruz-Jentoft, Alfonso Jose
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Cherubini, Antonio
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Dawson-Hughes, Bess
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Fielding, Roger A.
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Fuggle, Nicholas
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Halbout, Philippe
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Kanis, John A.
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Kaufman, J.M.
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Lamy, Olivier
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Laslop, Andrea
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Prieto Yerro, María Concepción
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Rademecker, Regis Pierre
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Thiyagarajan, Jotheeswaran Amuthavalli
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Thomas, Thierry
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Veronese, Nicola
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de Wit, Marten
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Reginster, Jean Yves
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Rizzoli, Rene
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Chevalley, Thierry, Brandi, M.L., Cashman, Kevin D., Cavalier, Etienne, Harvey, Nicholas, Maggi, Stefania, Cooper, Cyrus, Al-Daghri, Nasser M., Bock, Oliver, Bruyère, Olivier, Rosa, Mario M., Cortet, B., Cruz-Jentoft, Alfonso Jose, Cherubini, Antonio, Dawson-Hughes, Bess, Fielding, Roger A., Fuggle, Nicholas, Halbout, Philippe, Kanis, John A., Kaufman, J.M., Lamy, Olivier, Laslop, Andrea, Prieto Yerro, María Concepción, Rademecker, Regis Pierre, Thiyagarajan, Jotheeswaran Amuthavalli, Thomas, Thierry, Veronese, Nicola, de Wit, Marten, Reginster, Jean Yves and Rizzoli, Rene (2022) Role of Vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group. Aging Clinical and Experimental Research. (doi:10.1007/s40520-022-02279-6).

Record type: Article

Abstract

Vitamin D is a key component for optimal growth and for calcium–phosphate homeostasis. Skin photosynthesis is the main source of vitamin D. Limited sun exposure and insufficient dietary vitamin D supply justify vitamin D supplementation in certain age groups. In older adults, recommended doses for vitamin D supplementation vary between 200 and 2000 IU/day, to achieve a goal of circulating 25-hydroxyvitamin D (calcifediol) of at least 50 nmol/L. The target level depends on the population being supplemented, the assessed system, and the outcome. Several recent large randomized trials with oral vitamin D regimens varying between 2000 and 100,000 IU/month and mostly conducted in vitamin D-replete and healthy individuals have failed to detect any efficacy of these approaches for the prevention of fracture and falls. Considering the well-recognized major musculoskeletal disorders associated with severe vitamin D deficiency and taking into account a possible biphasic effects of vitamin D on fracture and fall risks, an European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group convened, carefully reviewed, and analyzed the meta-analyses of randomized controlled trials on the effects of vitamin D on fracture risk, falls or osteoarthritis, and came to the conclusion that 1000 IU daily should be recommended in patients at increased risk of vitamin D deficiency. The group also addressed the identification of patients possibly benefitting from a vitamin D loading dose to achieve early 25-hydroxyvitamin D therapeutic level or from calcifediol administration.

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Accepted/In Press date: 10 October 2022
e-pub ahead of print date: 26 October 2022
Keywords: Falls, Fragility fracture, Osteoarthritis, Vitamin D

Identifiers

Local EPrints ID: 471444
URI: http://eprints.soton.ac.uk/id/eprint/471444
ISSN: 1594-0667
PURE UUID: 647512ea-97fa-45c2-8a2b-68594d6f187a
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 08 Nov 2022 18:27
Last modified: 26 Nov 2022 02:39

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Contributors

Author: Thierry Chevalley
Author: M.L. Brandi
Author: Kevin D. Cashman
Author: Etienne Cavalier
Author: Nicholas Harvey ORCID iD
Author: Stefania Maggi
Author: Cyrus Cooper ORCID iD
Author: Nasser M. Al-Daghri
Author: Oliver Bock
Author: Olivier Bruyère
Author: Mario M. Rosa
Author: B. Cortet
Author: Alfonso Jose Cruz-Jentoft
Author: Antonio Cherubini
Author: Bess Dawson-Hughes
Author: Roger A. Fielding
Author: Nicholas Fuggle
Author: Philippe Halbout
Author: John A. Kanis
Author: J.M. Kaufman
Author: Olivier Lamy
Author: Andrea Laslop
Author: María Concepción Prieto Yerro
Author: Regis Pierre Rademecker
Author: Jotheeswaran Amuthavalli Thiyagarajan
Author: Thierry Thomas
Author: Nicola Veronese
Author: Marten de Wit
Author: Jean Yves Reginster
Author: Rene Rizzoli

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