READ ME File For: COMSOL data files for "3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast"

Dataset DOI: 10.5258/SOTON/D2417 

Date that the file was created: October, 2022

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GENERAL INFORMATION
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ReadMe Author: Rohan Lewis, University of Southampton

Date of data collection: 2018-2022

Information about geographic location of data collection: Southampton, UK

Related projects:


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SHARING/ACCESS INFORMATION
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Licenses/restrictions placed on the data, or limitations of reuse: CCBY

Recommended citation for the data: 

This dataset supports the publication: 
AUTHORS: Rohan M Lewis, Harikesan Baskaran, Jools Green, Stanimir Tashev, Eleni Paleologou, Emma M Lofthouse, Jane K Cleal, Anton Page, David S Chatelet, Patricia Goggin, Bram G Sengers.
TITLE:Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast
JOURNAL: iScience
PAPER DOI IF KNOWN:

Links to other publicly accessible locations of the data: A preprint is also available in Biorxiv doi: https://doi.org/10.1101/2022.01.26.477815

Links/relationships to ancillary or related data sets: SBFSEM image stacks https://dx.doi.org/10.6019/EMPIAR-10967 


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DATA & FILE OVERVIEW
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This dataset contains: COMSOL(COMSOL Multiphysics v5.5; COMSOL AB, Stockholm, Sweden) input files for each of the nanopores simulated in our study "Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast"

[File list read,e/txt, NP1.mph, NP2.mph, NP3.mph, NP4.mph, NP5.mph, NP6.mph, NP7.mph, NP8.mph, NP9.mph, NP10.mph inside the folder "Nanopore COMSOL files. Each '.mph' file contains the data to simulate one nanopore.

Relationship between files, if important for context: each file contains one data for nanopore

Additional related data collected that was not included in the current data package:

If data was derived from another source, list source: 

If there are there multiple versions of the dataset, list the file updated, when and why update was made:



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METHODOLOGICAL INFORMATION
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Description of methods used for collection/generation of data: <Include links or references to publications or other documentation containing experimental design or protocols used in data collection>

Methods for processing the data: Human placental villi were collected from uncomplicated term placentas, processed for and and imaged by serial block face scanning election microscopy. nanopores were then segmented form regions of these image stacks and this data used for analysis in COMSOL

Software- or Instrument-specific information needed to interpret the data, including software and hardware version numbers:

Standards and calibration information, if appropriate: NA

Environmental/experimental conditions: Human placental villi collected from uncomplicated term placentas.

Describe any quality-assurance procedures performed on the data: NA

People involved with sample collection, processing, analysis and/or submission: Rohan M Lewis, Harikesan Baskaran, Jools Green, Stanimir Tashev, Eleni Paleologou, Emma M Lofthouse, Jane K Cleal, Anton Page, David S Chatelet, Patricia Goggin, Bram G Sengers.


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DATA-SPECIFIC INFORMATION <Create sections for each datafile or set, as appropriate>
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Number of variables: NA

Number of cases/rows: NA

Variable list, defining any abbreviations, units of measure, codes or symbols used: meters
   
Missing data codes: NA

Specialised formats or other abbreviations used:  COMSOL files '.mph'