Immunobiological aspects of vaccines in pregnancy: Infant perspective
Immunobiological aspects of vaccines in pregnancy: Infant perspective
Vaccination in pregnancy is an effective means of protecting infants from infections until the period of greatest susceptibility of severe disease has passed, or until protection has been achieved by routine infant vaccinations. However, it is becoming increasingly recognized that vaccination may have additional implications for the infant other than passive protection via placental antibody transfer. Here we consider two aspects of recent debate with regards to infant health following vaccination in pregnancy: Firstly, we discuss the potential interference of maternally-derived vaccine-specific antibody with infant responses to primary vaccination, and consider the underlying mechanisms for this inhibitory effect, the age at which it disappears, and the clinical implications; Secondly, it has been observed that significantly higher vaccine-specific secretory IgA is present in the breastmilk of women who have been vaccinated in pregnancy, and we therefore discuss the potential for additional protection to be conferred to the newborn via alteration of breastmilk composition.
Blunting, Breastfeeding, Breastmilk, Diphtheria, Infant, Interference, Pertussis, Pregnancy, Tetanus, Vaccination
67-86
Wilcox, Christopher R.
e2c4c36a-e2e5-43a5-9fd6-7198cc15dd53
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
29 November 2019
Wilcox, Christopher R.
e2c4c36a-e2e5-43a5-9fd6-7198cc15dd53
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
Wilcox, Christopher R. and Jones, Christine E.
(2019)
Immunobiological aspects of vaccines in pregnancy: Infant perspective.
In,
Elke, E. and Leuridan, Marta C.
(eds.)
Maternal Immunization.
Academic Press, .
(doi:10.1016/B978-0-12-814582-1.00004-8).
Record type:
Book Section
Abstract
Vaccination in pregnancy is an effective means of protecting infants from infections until the period of greatest susceptibility of severe disease has passed, or until protection has been achieved by routine infant vaccinations. However, it is becoming increasingly recognized that vaccination may have additional implications for the infant other than passive protection via placental antibody transfer. Here we consider two aspects of recent debate with regards to infant health following vaccination in pregnancy: Firstly, we discuss the potential interference of maternally-derived vaccine-specific antibody with infant responses to primary vaccination, and consider the underlying mechanisms for this inhibitory effect, the age at which it disappears, and the clinical implications; Secondly, it has been observed that significantly higher vaccine-specific secretory IgA is present in the breastmilk of women who have been vaccinated in pregnancy, and we therefore discuss the potential for additional protection to be conferred to the newborn via alteration of breastmilk composition.
This record has no associated files available for download.
More information
Published date: 29 November 2019
Additional Information:
Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.
Keywords:
Blunting, Breastfeeding, Breastmilk, Diphtheria, Infant, Interference, Pertussis, Pregnancy, Tetanus, Vaccination
Identifiers
Local EPrints ID: 471850
URI: http://eprints.soton.ac.uk/id/eprint/471850
PURE UUID: 2585b420-6f2e-4e01-92ed-7dd5deb23abc
Catalogue record
Date deposited: 21 Nov 2022 17:57
Last modified: 06 Jun 2024 01:58
Export record
Altmetrics
Contributors
Editor:
E. Elke
Editor:
Marta C. Leuridan
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
