READ ME File For 'Supplementary data to support the Southampton Doctoral thesis 'The causes and consequences of clonal haematopoiesis''

Dataset DOI: 10.5258/SOTON/D2351

ReadMe Author: Ahmed A. Z. Dawoud, University of Southampton ORCID ID: 0000-0003-0164-7773

This dataset supports the thesis entitled The causes and consequences of clonal haematopoiesis
AWARDED BY: Univeristy of Southampton
DATE OF AWARD: [2022]

DESCRIPTION OF THE DATA
The dataset were generated by utilising genetic and phenotypic data from UK Biobank and include the calls of both mosaic chromosmoal events, and putattive somatic driver variants.

This dataset contains:
The dataset consists of two files.
(i) Supplementary tables of chapter 3 (Supplementary Tables 3-1 to 3-6)
(ii) supplementary tables of chapter 4. (Supplementary Tables 4-1 to 4-3)




Date of data collection: [2018-2022]

Information about geographic location of data collection: 

Licence:
UK Biobank received ethical approval from the North West multi-centre Research Ethics Committee (REC reference 11/NW/0382). My study was undertaken as part of the UK Biobank approved project ID 35273: Myeloproliferative neoplasms and clonal haematopoiesis (Principal Investigator N.C.P. Cross) with local approval (ERGO II ID 61730: the clinical significance of clonal haematopoiesis). 

Related projects/Funders:
Lady Tata Memorial Trust

Related publication:
Dawoud, A.A.Z., Tapper, W.J. & Cross, N.C.P. Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking. Leukemia 34, 2660–2672 (2020). https://doi.org/10.1038/s41375-020-0896-8
Dawoud, A.A.Z., Gilbert, R.D., Tapper, W.J. et al. Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease. Leukemia 36, 507–515 (2022). https://doi.org/10.1038/s41375-021-01382-3


Date that the file was created: July, 2022