A scoping review: urinary markers of metabolic maturation in preterm infants and future interventions to improve growth
A scoping review: urinary markers of metabolic maturation in preterm infants and future interventions to improve growth
Background: growth failure in infants born preterm is a significant issue, increasing the risk of poorer neurodevelopmental outcomes and metabolic syndrome later in life. During the first 1000 days of life biological systems mature rapidly involving developmental programming, cellular senescence, and metabolic maturation, regulating normal growth and development. However, little is known about metabolic maturation in infants born preterm and the relationship with growth.
Objective: to examine the available evidence on urinary markers of metabolic maturation and their relationship with growth in infants born preterm. Eligibility criteria: Studies including in this scoping review using qualitative or quantitative methods to describe urinary markers of metabolic maturation and the relationship with growth in infants born preterm.
Results: after a screening process 15 titles were included in this review, from 1998-2021 drawing from China (n = 1), Italy (n = 3), Germany (n = 3), Greece (n = 1), Japan (n = 2), Norway (n = 1), Portugal (n = 1), Spain (n = 2) and USA (n = 1). The included studies examined urinary metabolites in 1131 infants. A content analysis identified 4 overarching themes relating to; (i) metabolic maturation relative to gestational age, (ii) metabolic signature and changes in urinary metabolites over time, (iii) nutrition and (iv) growth.
Conclusion: the results of this scoping review suggest there are considerable gaps in our knowledge relating to factors associated with metabolic instability, what constitutes normal maturation of preterm infants, and how the development of reference phenome age z scores for metabolites of interest could improve nutritional and growth outcomes.
growth, infants, metabolic maturation, preterm, urinary metabolites
Marino, Luise V
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Paulson, Simone
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Ashton, James J
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Weeks, Charlotte
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Young, Aneurin
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Pappachan, John V
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Swann, Jonathan
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Johnson, Mark J
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Beattie, Robert Mark
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October 2022
Marino, Luise V
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Paulson, Simone
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Ashton, James J
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Weeks, Charlotte
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Young, Aneurin
cf3d7c90-4f55-4467-a59c-a84b5e5915ed
Pappachan, John V
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Swann, Jonathan
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Johnson, Mark J
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Beattie, Robert Mark
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Marino, Luise V, Paulson, Simone, Ashton, James J, Weeks, Charlotte, Young, Aneurin, Pappachan, John V, Swann, Jonathan, Johnson, Mark J and Beattie, Robert Mark
(2022)
A scoping review: urinary markers of metabolic maturation in preterm infants and future interventions to improve growth.
Nutrients, 14 (19), [3957].
(doi:10.3390/nu14193957).
Abstract
Background: growth failure in infants born preterm is a significant issue, increasing the risk of poorer neurodevelopmental outcomes and metabolic syndrome later in life. During the first 1000 days of life biological systems mature rapidly involving developmental programming, cellular senescence, and metabolic maturation, regulating normal growth and development. However, little is known about metabolic maturation in infants born preterm and the relationship with growth.
Objective: to examine the available evidence on urinary markers of metabolic maturation and their relationship with growth in infants born preterm. Eligibility criteria: Studies including in this scoping review using qualitative or quantitative methods to describe urinary markers of metabolic maturation and the relationship with growth in infants born preterm.
Results: after a screening process 15 titles were included in this review, from 1998-2021 drawing from China (n = 1), Italy (n = 3), Germany (n = 3), Greece (n = 1), Japan (n = 2), Norway (n = 1), Portugal (n = 1), Spain (n = 2) and USA (n = 1). The included studies examined urinary metabolites in 1131 infants. A content analysis identified 4 overarching themes relating to; (i) metabolic maturation relative to gestational age, (ii) metabolic signature and changes in urinary metabolites over time, (iii) nutrition and (iv) growth.
Conclusion: the results of this scoping review suggest there are considerable gaps in our knowledge relating to factors associated with metabolic instability, what constitutes normal maturation of preterm infants, and how the development of reference phenome age z scores for metabolites of interest could improve nutritional and growth outcomes.
Text
nutrients-14-03957-v2
- Version of Record
More information
Accepted/In Press date: 20 September 2022
Published date: October 2022
Additional Information:
Funding Information:
This work has received funding from the British Dietetic Association General Education Trust Fund (Ref: 21/05). A.Y. and M.J.J. are supported by the National Institute for Health Research Southampton Biomedical Research Centre.
Funding Information:
British Dietetic Association General Education Trust Fund for supporting this research and the University of Southampton Library specialists in helping to define the search strategy.
Publisher Copyright:
© 2022 by the authors.
Keywords:
growth, infants, metabolic maturation, preterm, urinary metabolites
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Local EPrints ID: 472212
URI: http://eprints.soton.ac.uk/id/eprint/472212
ISSN: 2072-6643
PURE UUID: 1df3bc7f-459e-43cf-93e4-eb299c618e2c
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Date deposited: 29 Nov 2022 17:42
Last modified: 17 Mar 2024 04:01
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Contributors
Author:
Luise V Marino
Author:
Simone Paulson
Author:
James J Ashton
Author:
Charlotte Weeks
Author:
Aneurin Young
Author:
John V Pappachan
Author:
Mark J Johnson
Author:
Robert Mark Beattie
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