It's time: A commentary on fear extinction in the human brain using fMRI
It's time: A commentary on fear extinction in the human brain using fMRI
The recent meta-analysis by Fullana et al. (2018) is both timely and significant, providing a vital milestone towards understanding the neural networks involved in threat extinction in humans. Fullana et al. (2018) examined both threat extinction and recall separately using sophisticated meta-analytic methods based on raw contrast maps. Importantly, the meta-analysis highlighted a lack of consistent activation across studies for key neural “players” in the threat extinction circuit: the amygdala and ventromedial prefrontal cortex (vmPFC). In the current commentary, we highlight reasons for which this key circuitry may not have resulted from this meta-analysis, and call for a ‘gold standard’ in the examination of threat extinction using fMRI.
321-322
Morriss, Jayne
a6005806-07cf-4283-8766-900003a7306f
Hoare, Shannon
67c00a57-288a-44be-bab5-9bbd9f6c0ba1
van Reekum, Carien M
56010ab6-5a14-4c5a-b463-eb2159b3684c
1 November 2018
Morriss, Jayne
a6005806-07cf-4283-8766-900003a7306f
Hoare, Shannon
67c00a57-288a-44be-bab5-9bbd9f6c0ba1
van Reekum, Carien M
56010ab6-5a14-4c5a-b463-eb2159b3684c
Morriss, Jayne, Hoare, Shannon and van Reekum, Carien M
(2018)
It's time: A commentary on fear extinction in the human brain using fMRI.
Neuroscience Biobehavioral Reviews, 94, .
(doi:10.1016/j.neubiorev.2018.06.025).
Abstract
The recent meta-analysis by Fullana et al. (2018) is both timely and significant, providing a vital milestone towards understanding the neural networks involved in threat extinction in humans. Fullana et al. (2018) examined both threat extinction and recall separately using sophisticated meta-analytic methods based on raw contrast maps. Importantly, the meta-analysis highlighted a lack of consistent activation across studies for key neural “players” in the threat extinction circuit: the amygdala and ventromedial prefrontal cortex (vmPFC). In the current commentary, we highlight reasons for which this key circuitry may not have resulted from this meta-analysis, and call for a ‘gold standard’ in the examination of threat extinction using fMRI.
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e-pub ahead of print date: 30 June 2018
Published date: 1 November 2018
Additional Information:
Crown Copyright © 2018 Published by Elsevier Ltd. All rights reserved.
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Local EPrints ID: 472465
URI: http://eprints.soton.ac.uk/id/eprint/472465
PURE UUID: 85007dd3-787e-4c71-966c-96b24dd7f0f5
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Date deposited: 06 Dec 2022 17:34
Last modified: 17 Mar 2024 04:14
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Author:
Jayne Morriss
Author:
Shannon Hoare
Author:
Carien M van Reekum
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