The genomics of hairy cell Leukaemia and splenic diffuse red pulp Lymphoma
The genomics of hairy cell Leukaemia and splenic diffuse red pulp Lymphoma
Classical hairy cell leukaemia (HCLc), its variant form (HCLv), and splenic diffuse red pulp lymphoma (SDRPL) constitute a subset of relatively indolent B cell tumours, with low incidence rates of high-grade transformations, which primarily involve the spleen and bone marrow and are usually associated with circulating tumour cells characterised by villous or irregular cytoplasmic borders. The primary aim of this review is to summarise their cytogenetic, genomic, immunogenetic, and epigenetic features, with a particular focus on the clonal BRAFV600E mutation, present in most cases currently diagnosed with HCLc. We then reflect on their cell of origin and pathogenesis as well as present the clinical implications of improved biological understanding, extending from diagnosis to prognosis assessment and therapy response.
BRAFV600E, HCLc, HCLv, Hairy cell leukaemia, SDRPL, Tbet
Oscier, David
2e7f0cc1-93e2-441e-857d-7314efae08ec
Stamatopoulos, Kostas
04185c9f-28ac-4693-bcff-4b6f2081de5c
Mirandari, Amatta
b8640936-4b35-47c5-b6f1-f4d81ab6e2f6
Strefford, Jonathan
3782b392-f080-42bf-bdca-8aa5d6ca532f
29 January 2022
Oscier, David
2e7f0cc1-93e2-441e-857d-7314efae08ec
Stamatopoulos, Kostas
04185c9f-28ac-4693-bcff-4b6f2081de5c
Mirandari, Amatta
b8640936-4b35-47c5-b6f1-f4d81ab6e2f6
Strefford, Jonathan
3782b392-f080-42bf-bdca-8aa5d6ca532f
Oscier, David, Stamatopoulos, Kostas, Mirandari, Amatta and Strefford, Jonathan
(2022)
The genomics of hairy cell Leukaemia and splenic diffuse red pulp Lymphoma.
Cancers, 14 (3), [697].
(doi:10.3390/cancers14030697).
Abstract
Classical hairy cell leukaemia (HCLc), its variant form (HCLv), and splenic diffuse red pulp lymphoma (SDRPL) constitute a subset of relatively indolent B cell tumours, with low incidence rates of high-grade transformations, which primarily involve the spleen and bone marrow and are usually associated with circulating tumour cells characterised by villous or irregular cytoplasmic borders. The primary aim of this review is to summarise their cytogenetic, genomic, immunogenetic, and epigenetic features, with a particular focus on the clonal BRAFV600E mutation, present in most cases currently diagnosed with HCLc. We then reflect on their cell of origin and pathogenesis as well as present the clinical implications of improved biological understanding, extending from diagnosis to prognosis assessment and therapy response.
Text
cancers-14-00697-v3
- Version of Record
More information
Accepted/In Press date: 25 January 2022
Published date: 29 January 2022
Keywords:
BRAFV600E, HCLc, HCLv, Hairy cell leukaemia, SDRPL, Tbet
Identifiers
Local EPrints ID: 472540
URI: http://eprints.soton.ac.uk/id/eprint/472540
ISSN: 2072-6694
PURE UUID: 4a05297f-ab20-445c-928a-9d4469df5572
Catalogue record
Date deposited: 07 Dec 2022 18:06
Last modified: 17 Mar 2024 02:59
Export record
Altmetrics
Contributors
Author:
David Oscier
Author:
Kostas Stamatopoulos
Author:
Amatta Mirandari
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
