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Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"

Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"
Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"
These are the burden test results (summary statistics) for the publication: "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s Disease", Nature Genetics, 2022. Format: tab-separated-value. Fields: gene_stable_id: Ensembl gene id gene_name: standard gene name pvalue: burden test significance (likelihood ratio test, population structure correction based on 6 PCA components) cmac_all: sum of minor allele dosages across all contributing samples and variants group: variant group (LOF, LOF+REVEL>=75, LOF+REVEL>=50, LOF+REVEL>=25, see publication methods for further selection criteria). beta/se: beta/se of logistic ordinal regression (see publication methods). Positive = risk-increasing. Negative = risk-decreasing.
Zenodo
Hummerich, Holger
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Duijn, Cornelia M van
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Norsworthy, Penny J.
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Fernandez, Maria Victoria
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Spaendonk, Resie van
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Hulsman, Marc
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Sanchez-Juan, Pascual
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Bellenguez, Céline
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(2022) Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease". Zenodo doi:10.5281/zenodo.6818051 [Dataset]

Record type: Dataset

Abstract

These are the burden test results (summary statistics) for the publication: "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s Disease", Nature Genetics, 2022. Format: tab-separated-value. Fields: gene_stable_id: Ensembl gene id gene_name: standard gene name pvalue: burden test significance (likelihood ratio test, population structure correction based on 6 PCA components) cmac_all: sum of minor allele dosages across all contributing samples and variants group: variant group (LOF, LOF+REVEL>=75, LOF+REVEL>=50, LOF+REVEL>=25, see publication methods for further selection criteria). beta/se: beta/se of logistic ordinal regression (see publication methods). Positive = risk-increasing. Negative = risk-decreasing.

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More information

Published date: 11 July 2022

Identifiers

Local EPrints ID: 472655
URI: http://eprints.soton.ac.uk/id/eprint/472655
PURE UUID: 88a9f9c0-cc3a-459d-ac89-5b89d5dec700
ORCID for Clive Holmes: ORCID iD orcid.org/0000-0003-1999-6912

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Date deposited: 13 Dec 2022 17:43
Last modified: 19 Jul 2023 01:35

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Contributors

Contributor: Holger Hummerich
Contributor: Margaret A. Pericak-Vance
Contributor: Rachel Raybould
Contributor: Erik Sistermans
Contributor: Rita Guerreiro
Contributor: Richard Redon
Contributor: Najaf Amin
Contributor: Pau Pastor
Contributor: Daoud Sie
Contributor: Claudine Berr
Contributor: Anne Boland
Contributor: Anita L DeStefano
Contributor: John C. van Swieten
Contributor: Jennifer S. Yokoyama
Contributor: Iris Jansen
Contributor: Davide Seripa
Contributor: Sudha Seshadri
Contributor: Dominique Campion
Contributor: Yann Le Guen
Contributor: Sandro Sorbi
Contributor: Stéphanie Debette
Contributor: Eden R Martin
Contributor: Clive Holmes ORCID iD
Contributor: Philip Scheltens
Contributor: Gianfranco Spalletta
Contributor: André G Uitterlinden
Contributor: Olivier Quenez
Contributor: Michael Wagner
Contributor: Pieter Jelle de Visser
Contributor: Li-San Wang
Contributor: Rachel Marshall
Contributor: Stéphane Rousseau
Contributor: Jean-Charles Lambert
Contributor: Shahzad Ahmad
Contributor: Amit Kawalia
Contributor: M. Arfan Ikram
Contributor: Wiesje M. van der Flier
Contributor: Pascual Sanchez-Juan
Contributor: Céline Bellenguez
Contributor: Marcel J.T. Reinders
Contributor: Antonio Daniele
Contributor: Sven J. van der Lee
Contributor: Jean-François Dartigues
Contributor: M. Kamran Ikram
Contributor: Nick C. Fox
Contributor: Jean-François Deleuze
Contributor: Cornelia M van Duijn
Contributor: Penny J. Norsworthy
Contributor: Lauren Luckcuck
Contributor: Alun Meggy
Contributor: Henne Holstege
Contributor: Valerio Napolioni
Contributor: Maria Victoria Fernandez
Contributor: J. Nicholas Cochran
Contributor: Philippe Amouyel
Contributor: Julie Williams
Contributor: John Hardy
Contributor: Marcel M. A. M. Mannens
Contributor: Carlo Masullo
Contributor: Merel O. Mol
Contributor: Richard M. Myers
Contributor: Anne-Claire Richard
Contributor: Gaël Nicolas
Contributor: Lindsay A. Farrer
Contributor: Alzheimer's Disease Neuroimaging Initiative (ADNI) database
Contributor: Gary W. Beecham
Contributor: Richard Mayeux
Contributor: Niccólo Tesi
Contributor: Joshua C. Bis
Contributor: Jose Bras
Contributor: Oriol Dols-Icardo
Contributor: Paola Bossù
Contributor: Robert Kraaij
Contributor: Alfredo Ramirez
Contributor: Nicola Denning
Contributor: Carlos Cruchaga
Contributor: Patrizia Mecocci
Contributor: Daniela Galimberti
Contributor: Resie van Spaendonk
Contributor: Betty Tijms
Contributor: Aline Zarea
Contributor: Jonathan L. Haines
Contributor: Afina W. Lemstra
Contributor: Simon Mead
Contributor: Florence Pasquier
Contributor: Michael Greicius
Contributor: Hans Gille
Contributor: Benjamin Grenier-Boley
Contributor: Femke Bouwman
Contributor: Marc Hulsman
Contributor: Camille Charbonnier
Contributor: Natalie S. Ryan
Contributor: Detelina Grozeva
Contributor: David Wallon
Contributor: Salha Saad
Contributor: Alberto Lleó
Contributor: Kevin Morgan
Contributor: Jordi Clarimon
Contributor: Emmanuelle Genin
Contributor: Fernando Rivadeneira
Contributor: Marc Lathrop
Contributor: Gerard D. Schellenberg
Contributor: Benedetta Nacmias
Contributor: Jonathan M. Schott
Contributor: Jeroen G.J. van Rooij
Contributor: Adam C Naj
Contributor: Rebecca Sims
Contributor: Steffi G Riedel-Heller

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