Method and apparatus for obtaining chemical and/or material specific information of a sample using light scattered by Rayleigh scattering and/or Raman

Sumeet, Mahajan, Niall, Hanrahan and Konstaninos, Bourdakos (Inventors) (2021) Method and apparatus for obtaining chemical and/or material specific information of a sample using light scattered by Rayleigh scattering and/or Raman. GB2592081.

Record type: Patent

Abstract

Two images of a sample 300 are obtained. Each image indicates the intensity of Rayleigh scattered light 203 i) for incident light 201 of a different wavelength, or ii) for incident light 201 of a different polarisation state, or iii) of scattered light 203 of a different polarisation state. Alternatively, each image indicates the intensity of Raman scattered light 203 i) of a different wavelength, or ii) for incident light 201 of a different polarisation state, or iii) for incident light 201 of a different polarisation state. Chemical and/or material specific information of the sample 300 is determined based on the change in intensity of the scattered light 203 in dependence on the change in wavelength and/or polarisation of the incident and/or scattered light. The determination step may involve a look-up table, direct calculation, classification via e.g. principal component analysis or a neural network. Light sheet microscopy may be used.

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