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Temporal evolution in quality of life following melphalan percutaneous hepatic perfusion for patients with metastatic uveal melanoma

Temporal evolution in quality of life following melphalan percutaneous hepatic perfusion for patients with metastatic uveal melanoma
Temporal evolution in quality of life following melphalan percutaneous hepatic perfusion for patients with metastatic uveal melanoma
Background: recent studies have demonstrated a clear survival benefit of melphalan percutaneous hepatic perfusion (M-PHP) for liver metastases from ocular melanoma (mUM). Importantly, the survival benefit relating to each treatment cycle must be carefully balanced with changes in patient Quality of Life. We contribute our single centre findings on the temporal change in the quality of life after M-PHP therapy.

Methods: we performed a retrospective analysis of the change in quality of life (QoL) using the Functional Assessment of Cancer Therapy - General (FACT-G) with mUM patients receiving M‐PHP at our institutions (n = 13). The FACT-G score which comprises physical (PWB), social (SWB), emotional (EWB) and functional (FWB) wellbeing were measured pre-procedure and at day 1, day of discharge, 7, 14 and 28 days after M-PHP therapy. Paired t-test was used to assess for any significant change in each QoL domain.

Results: the baseline FACT-G score was 93.4 out of 108 +/- 14.7 (mean +/- std). Quality of life scoring significantly decreased immediately after the procedure (day 1; 84.8 +/- 13.1, p = 0.01) and gradually improved over time, with no significant difference in total score by the day of discharge; 88.7 +/- 13.7, c.f baseline p = 0.22). By day 28, there was a trend for overall improved QoL (96.6 +/-9.3, p = 0.25). Sub-score analysis revealed that by day 28 there was a statistically significant improvement in EWB (p = 0.02), a trend towards improved scores in PWB and SWB domains. FWB was slightly below baseline by day 28 (23.8 vs 23.2).

Conclusions: quality of life following M-PHP decreases immediately after therapy and is not significantly different from baseline by the day of discharge. By day 28 there is a trend towards improved overall quality of life. This study could provide the basis for determining the optimal time between treatment cycles.
0732-183X
Vigneswaran, Ganesh
4e3865ad-1a15-4a27-b810-55348e7baceb
Woodcock, Pippa
3c2746e9-ccaf-4d1b-8978-0c08688177e6
Gibson, Tom
b0d53572-14bd-4614-8ddd-6d69135a90bf
Patel, Shian
f91303ab-8aef-42b3-a5c9-5e6d4fbdfaef
Adil, Maryam
14abcc12-8ccb-47be-bc91-2a9fae910662
Wheater, Matthew
3691c3d8-8589-4693-a0dc-c6a8648cd7df
Karydis, Ioannis
95a2388c-7165-40e1-8b73-87234caea36d
Gupta, Sanjay
3eae7ae7-8915-4c1f-8f28-2882160b9a62
Stedman, Brian
180a4644-f670-4da1-84db-9d5640e4ec1d
Modi, Sachin
caef086a-dda5-418a-ada8-fc042e6e0b18
Vigneswaran, Ganesh
4e3865ad-1a15-4a27-b810-55348e7baceb
Woodcock, Pippa
3c2746e9-ccaf-4d1b-8978-0c08688177e6
Gibson, Tom
b0d53572-14bd-4614-8ddd-6d69135a90bf
Patel, Shian
f91303ab-8aef-42b3-a5c9-5e6d4fbdfaef
Adil, Maryam
14abcc12-8ccb-47be-bc91-2a9fae910662
Wheater, Matthew
3691c3d8-8589-4693-a0dc-c6a8648cd7df
Karydis, Ioannis
95a2388c-7165-40e1-8b73-87234caea36d
Gupta, Sanjay
3eae7ae7-8915-4c1f-8f28-2882160b9a62
Stedman, Brian
180a4644-f670-4da1-84db-9d5640e4ec1d
Modi, Sachin
caef086a-dda5-418a-ada8-fc042e6e0b18

Vigneswaran, Ganesh, Woodcock, Pippa, Gibson, Tom, Patel, Shian, Adil, Maryam, Wheater, Matthew, Karydis, Ioannis, Gupta, Sanjay, Stedman, Brian and Modi, Sachin (2022) Temporal evolution in quality of life following melphalan percutaneous hepatic perfusion for patients with metastatic uveal melanoma. Journal of Clinical Oncology, 40 (16). (doi:10.1200/JCO.2022.40.16_suppl.e21520).

Record type: Meeting abstract

Abstract

Background: recent studies have demonstrated a clear survival benefit of melphalan percutaneous hepatic perfusion (M-PHP) for liver metastases from ocular melanoma (mUM). Importantly, the survival benefit relating to each treatment cycle must be carefully balanced with changes in patient Quality of Life. We contribute our single centre findings on the temporal change in the quality of life after M-PHP therapy.

Methods: we performed a retrospective analysis of the change in quality of life (QoL) using the Functional Assessment of Cancer Therapy - General (FACT-G) with mUM patients receiving M‐PHP at our institutions (n = 13). The FACT-G score which comprises physical (PWB), social (SWB), emotional (EWB) and functional (FWB) wellbeing were measured pre-procedure and at day 1, day of discharge, 7, 14 and 28 days after M-PHP therapy. Paired t-test was used to assess for any significant change in each QoL domain.

Results: the baseline FACT-G score was 93.4 out of 108 +/- 14.7 (mean +/- std). Quality of life scoring significantly decreased immediately after the procedure (day 1; 84.8 +/- 13.1, p = 0.01) and gradually improved over time, with no significant difference in total score by the day of discharge; 88.7 +/- 13.7, c.f baseline p = 0.22). By day 28, there was a trend for overall improved QoL (96.6 +/-9.3, p = 0.25). Sub-score analysis revealed that by day 28 there was a statistically significant improvement in EWB (p = 0.02), a trend towards improved scores in PWB and SWB domains. FWB was slightly below baseline by day 28 (23.8 vs 23.2).

Conclusions: quality of life following M-PHP decreases immediately after therapy and is not significantly different from baseline by the day of discharge. By day 28 there is a trend towards improved overall quality of life. This study could provide the basis for determining the optimal time between treatment cycles.

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More information

e-pub ahead of print date: 1 June 2022
Published date: 1 June 2022

Identifiers

Local EPrints ID: 472857
URI: http://eprints.soton.ac.uk/id/eprint/472857
ISSN: 0732-183X
PURE UUID: 37907d45-7d5c-4870-88fd-66ddb5adf7c1
ORCID for Ganesh Vigneswaran: ORCID iD orcid.org/0000-0002-4115-428X

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Date deposited: 20 Dec 2022 17:37
Last modified: 17 Mar 2024 04:06

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Contributors

Author: Pippa Woodcock
Author: Tom Gibson
Author: Shian Patel
Author: Maryam Adil
Author: Matthew Wheater
Author: Ioannis Karydis
Author: Sanjay Gupta
Author: Brian Stedman
Author: Sachin Modi

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