Value of p53 sequencing in the prognostication of head and neck cancer: a systematic review and meta-analysis
Value of p53 sequencing in the prognostication of head and neck cancer: a systematic review and meta-analysis
This review aimed to examine the relationship between TP53 mutational status, as determined by genomic sequencing, and survival in squamous cell carcinoma of the head and neck. The databases Medline, Embase, Web of Science (core collection), Scopus and Cochrane Library were searched from inception to April 2021 for studies assessing P53 status and survival. Qualitative analysis was carried out using the REMARK criteria. A meta-analyses was performed and statistical analysis was carried out to test the stability and reliability of results. Twenty-five studies met the inclusion criteria, of which fifteen provided enough data for quantitative evaluation. TP53 mutation was associated with worse overall survival (HR 1.75 [95% CI 1.45-2.10], p < 0.001), disease-specific survival (HR 4.23 [95% CI 1.19-15.06], p = 0.03), and disease-free survival (HR 1.80 [95% CI 1.28-2.53], p < 0.001). Qualitative assessment identified room for improvement and the pooled analysis of all anatomical subsites leads to heterogeneity that may erode the validity of the observed overall effect and its subsequent extrapolation and application to individual patients. Our systematic review and meta-analysis supports the utility of TP53 mutational as a prognostic factor for survival in head and neck squamous cell carcinoma. A well designed prospective, multi-centre trial is needed to definitively answer this question.
Head and Neck Neoplasms/genetics, Humans, Prospective Studies, Reproducibility of Results, Squamous Cell Carcinoma of Head and Neck/genetics, Tumor Suppressor Protein p53/genetics
20776
Basyuni, Shadi
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Nugent, Gareth
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Ferro, Ashley
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Barker, Eleanor
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Reddin, Ian
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Jones, Oliver
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Lechner, Matt
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O'Leary, Ben
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Jones, Terry
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Masterson, Liam
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Fenton, Tim
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Schache, Andrew
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1 December 2022
Basyuni, Shadi
c8dc210e-45c3-4494-9359-47c6875a3190
Nugent, Gareth
f24d9d85-e410-4c5f-9e57-0dd6534cbc69
Ferro, Ashley
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Barker, Eleanor
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Reddin, Ian
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Jones, Oliver
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Lechner, Matt
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O'Leary, Ben
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Jones, Terry
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Masterson, Liam
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Fenton, Tim
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Schache, Andrew
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Basyuni, Shadi, Nugent, Gareth, Ferro, Ashley, Barker, Eleanor, Reddin, Ian, Jones, Oliver, Lechner, Matt, O'Leary, Ben, Jones, Terry, Masterson, Liam, Fenton, Tim and Schache, Andrew
(2022)
Value of p53 sequencing in the prognostication of head and neck cancer: a systematic review and meta-analysis.
Scientific Reports, 12 (1), , [20776].
(doi:10.1038/s41598-022-25291-2).
Abstract
This review aimed to examine the relationship between TP53 mutational status, as determined by genomic sequencing, and survival in squamous cell carcinoma of the head and neck. The databases Medline, Embase, Web of Science (core collection), Scopus and Cochrane Library were searched from inception to April 2021 for studies assessing P53 status and survival. Qualitative analysis was carried out using the REMARK criteria. A meta-analyses was performed and statistical analysis was carried out to test the stability and reliability of results. Twenty-five studies met the inclusion criteria, of which fifteen provided enough data for quantitative evaluation. TP53 mutation was associated with worse overall survival (HR 1.75 [95% CI 1.45-2.10], p < 0.001), disease-specific survival (HR 4.23 [95% CI 1.19-15.06], p = 0.03), and disease-free survival (HR 1.80 [95% CI 1.28-2.53], p < 0.001). Qualitative assessment identified room for improvement and the pooled analysis of all anatomical subsites leads to heterogeneity that may erode the validity of the observed overall effect and its subsequent extrapolation and application to individual patients. Our systematic review and meta-analysis supports the utility of TP53 mutational as a prognostic factor for survival in head and neck squamous cell carcinoma. A well designed prospective, multi-centre trial is needed to definitively answer this question.
Text
s41598-022-25291-2
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e-pub ahead of print date: 1 December 2022
Published date: 1 December 2022
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© 2022, The Author(s).
Keywords:
Head and Neck Neoplasms/genetics, Humans, Prospective Studies, Reproducibility of Results, Squamous Cell Carcinoma of Head and Neck/genetics, Tumor Suppressor Protein p53/genetics
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Local EPrints ID: 472886
URI: http://eprints.soton.ac.uk/id/eprint/472886
ISSN: 2045-2322
PURE UUID: 3400db4d-9a30-48d1-8a98-758f2076251f
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Date deposited: 05 Jan 2023 17:39
Last modified: 17 Mar 2024 04:11
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Author:
Shadi Basyuni
Author:
Gareth Nugent
Author:
Ashley Ferro
Author:
Eleanor Barker
Author:
Ian Reddin
Author:
Oliver Jones
Author:
Matt Lechner
Author:
Ben O'Leary
Author:
Terry Jones
Author:
Liam Masterson
Author:
Andrew Schache
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