Impairment of sexual desire in treatment-resistant depression: Prevalence and correlates
Impairment of sexual desire in treatment-resistant depression: Prevalence and correlates
Background: Alterations of sexual functions are frequent in major depressive disorder (MDD), however there are little data on sexual functions in patients with treatment-resistant depression (TRD).
Aim: To assess sexual desire impairment in patients with TRD.
Methods: Baseline data were analyzed from an ongoing cohort study from an outpatient clinic specialized in TRD treatment in Brazil. The cohort comprised consecutive patients with the diagnosis of TRD that sought treatment in this center.
Main outcome measures: The Hamilton Depression Rating Scale (HAMD) Genital Symptoms Item (item 14) was used as a proxy to assess sexual desire impairment
Results: Sixty-five participants with TRD were included. There was sexual desire impairment in 67.7% of patients. Men (87.5%) were more affected than women (61.2%) and depression severity was associated with greater complaints of this aspect of sexual function.
Clinical Implications: Our findings suggest that health care professionals should systematically assess sexual desire in patients with TRD in daily clinical practice.
Strengths & Limitations: To our knowledge, this is the first study to assess impairment in sexual desire in TRD. A major limitation that need to be addressed in future studies is the reliance on item 14 of the HAMD, which was not designed specifically for assessing sexual dysfunction.
Conclusion: Participants with TRD had a high prevalence of sexual desire impairment, this being associated with greater depressive symptoms severity and male gender. Further longitudinal studies are needed, in larger samples, using specific instruments for assessing sexual dysfunction comparing TRD and non-TRD populations.
Depressive disorders, depression, Major, Libido, Sexual dysfunction
dos Santos Goncalves, Walter
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Dorte Halkjaer Lassen, Roseane
876862a3-c250-41af-a103-3ab1cd5ffa19
Sardinha, Aline
4df96023-6a58-4020-b8b8-62414acb4e17
Silva Friere Coutinho, Evandro
9d40bbfc-761d-4f08-9805-d0fbd4e3b2be
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Nardi, Antonio E
d1a9d5bc-9e01-480f-a9b2-2b894df7a78f
Appolinario, Jose Carlos
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22 November 2022
dos Santos Goncalves, Walter
04dfede9-6d8c-4722-915a-540287f7463b
Dorte Halkjaer Lassen, Roseane
876862a3-c250-41af-a103-3ab1cd5ffa19
Sardinha, Aline
4df96023-6a58-4020-b8b8-62414acb4e17
Silva Friere Coutinho, Evandro
9d40bbfc-761d-4f08-9805-d0fbd4e3b2be
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Nardi, Antonio E
d1a9d5bc-9e01-480f-a9b2-2b894df7a78f
Appolinario, Jose Carlos
41abf241-2bd3-470d-b265-48482552bf17
dos Santos Goncalves, Walter, Dorte Halkjaer Lassen, Roseane, Sardinha, Aline, Silva Friere Coutinho, Evandro, Baldwin, David, Nardi, Antonio E and Appolinario, Jose Carlos
(2022)
Impairment of sexual desire in treatment-resistant depression: Prevalence and correlates.
Primary Care Companion CNS Disorders.
(doi:10.4088/PCC.22m03275).
Abstract
Background: Alterations of sexual functions are frequent in major depressive disorder (MDD), however there are little data on sexual functions in patients with treatment-resistant depression (TRD).
Aim: To assess sexual desire impairment in patients with TRD.
Methods: Baseline data were analyzed from an ongoing cohort study from an outpatient clinic specialized in TRD treatment in Brazil. The cohort comprised consecutive patients with the diagnosis of TRD that sought treatment in this center.
Main outcome measures: The Hamilton Depression Rating Scale (HAMD) Genital Symptoms Item (item 14) was used as a proxy to assess sexual desire impairment
Results: Sixty-five participants with TRD were included. There was sexual desire impairment in 67.7% of patients. Men (87.5%) were more affected than women (61.2%) and depression severity was associated with greater complaints of this aspect of sexual function.
Clinical Implications: Our findings suggest that health care professionals should systematically assess sexual desire in patients with TRD in daily clinical practice.
Strengths & Limitations: To our knowledge, this is the first study to assess impairment in sexual desire in TRD. A major limitation that need to be addressed in future studies is the reliance on item 14 of the HAMD, which was not designed specifically for assessing sexual dysfunction.
Conclusion: Participants with TRD had a high prevalence of sexual desire impairment, this being associated with greater depressive symptoms severity and male gender. Further longitudinal studies are needed, in larger samples, using specific instruments for assessing sexual dysfunction comparing TRD and non-TRD populations.
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Impaired sexual desire in TRD - Final Version AAM
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Accepted/In Press date: 20 November 2022
Published date: 22 November 2022
Keywords:
Depressive disorders, depression, Major, Libido, Sexual dysfunction
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Local EPrints ID: 473203
URI: http://eprints.soton.ac.uk/id/eprint/473203
ISSN: 2155-7780
PURE UUID: 9c8bd7a0-b70d-462d-9af7-67db286216cf
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Date deposited: 12 Jan 2023 17:49
Last modified: 17 Mar 2024 07:36
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Contributors
Author:
Walter dos Santos Goncalves
Author:
Roseane Dorte Halkjaer Lassen
Author:
Aline Sardinha
Author:
Evandro Silva Friere Coutinho
Author:
Antonio E Nardi
Author:
Jose Carlos Appolinario
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