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UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases

UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases
UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases

Background/objectives: this study aims to describe the grading methods and baseline characteristics for UK Biobank (UKBB) participants who underwent retinal imaging in 2009–2010, and to characterise individuals with retinal features suggestive of age-related macular degeneration (AMD), glaucoma and retinopathy.

Methods: non-mydriatic colour fundus photographs and macular optical coherence tomography (OCT) scans were manually graded by Central Administrative Research Facility certified graders and quality assured by clinicians of the Network of Ophthalmic Reading Centres UK. Captured retinal features included those associated with AMD (≥1 drusen, pigmentary changes, geographic atrophy or exudative AMD; either imaging modality), glaucoma (≥0.7 cup-disc ratio, ≥0.2 cup-disc ratio difference between eyes, other abnormal disc features; photographs only) and retinopathy (characteristic features of diabetic retinopathy with or without microaneurysms; either imaging modality). Suspected cases of these conditions were characterised with reference to diagnostic records, physical and biochemical measurements.

Results: among 68,514 UKBB participants who underwent retinal imaging, the mean age was 57.3 years (standard deviation 8.2), 45.7% were men and 90.6% were of White ethnicity. A total of 64,367 participants had gradable colour fundus photographs and 68,281 had gradable OCT scans in at least one eye. Retinal features suggestive of AMD and glaucoma were identified in 15,176 and 2184 participants, of whom 125 (0.8%) and 188 (8.6%), respectively, had a recorded diagnosis. Of 264 participants identified to have retinopathy with microaneurysms, 251 (95.1%) had either diabetes or hypertension.

Conclusions: this dataset represents a valuable addition to what is currently available in UKBB, providing important insights to both ocular and systemic health.

0950-222X
2109-2116
Warwick, Alasdair N.
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Balaskas, Konstantinos
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Chan, M.
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Chua, S.
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Day, A.
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Desai, P.
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Dhillon, B.
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Dick, A.
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Doney, A.
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Egan, C.
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Ennis, S.
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Foster, P.
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Fruttiger, M.
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Gallacher, J.
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Garway-Heath, D.
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Gibson, J.
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Hammond, C.
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Hardcastle, A.
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Harding, S.
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Lotery, Andrew J.
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Moore, T.
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Morgan, J.
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Owen, C.
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Patel, P.
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Self, J.
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Williams, K.
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Williams, C.
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Zheng, Y.
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UKBB Eye and Vision Consortium
Warwick, Alasdair N.
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Curran, Katie
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Hamill, Barbra
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Stuart, Kelsey
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Khawaja, Anthony P.
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Foster, Paul J.
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Lotery, Andrew J.
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Quinn, Michael
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Madhusudhan, Savita
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Balaskas, Konstantinos
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Peto, Tunde
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Allen, N.
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Aslam, T.
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Atan, D.
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Black, G.
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Braithwaite, T.
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Carare, R.
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Chakravarthy, U.
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Chan, M.
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Chua, S.
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Day, A.
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Desai, P.
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Dhillon, B.
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Doney, A.
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Egan, C.
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Ennis, S.
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Foster, P.
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Fruttiger, M.
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Gallacher, J.
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Garway-Heath, D.
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Gibson, J.
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Hammond, C.
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Hardcastle, A.
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Harding, S.
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Lotery, Andrew J.
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Moore, T.
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Morgan, J.
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Owen, C.
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Patel, P.
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Self, J.
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Stratton, I.
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Sun, Z.
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Thomas, D.
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Williams, K.
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Williams, C.
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Zheng, Y.
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Warwick, Alasdair N., Curran, Katie, Hamill, Barbra, Stuart, Kelsey, Khawaja, Anthony P., Foster, Paul J., Lotery, Andrew J., Quinn, Michael, Madhusudhan, Savita, Balaskas, Konstantinos and Peto, Tunde , UKBB Eye and Vision Consortium (2023) UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases. Eye (Basingstoke), 37 (10), 2109-2116. (doi:10.1038/s41433-022-02298-7).

Record type: Article

Abstract

Background/objectives: this study aims to describe the grading methods and baseline characteristics for UK Biobank (UKBB) participants who underwent retinal imaging in 2009–2010, and to characterise individuals with retinal features suggestive of age-related macular degeneration (AMD), glaucoma and retinopathy.

Methods: non-mydriatic colour fundus photographs and macular optical coherence tomography (OCT) scans were manually graded by Central Administrative Research Facility certified graders and quality assured by clinicians of the Network of Ophthalmic Reading Centres UK. Captured retinal features included those associated with AMD (≥1 drusen, pigmentary changes, geographic atrophy or exudative AMD; either imaging modality), glaucoma (≥0.7 cup-disc ratio, ≥0.2 cup-disc ratio difference between eyes, other abnormal disc features; photographs only) and retinopathy (characteristic features of diabetic retinopathy with or without microaneurysms; either imaging modality). Suspected cases of these conditions were characterised with reference to diagnostic records, physical and biochemical measurements.

Results: among 68,514 UKBB participants who underwent retinal imaging, the mean age was 57.3 years (standard deviation 8.2), 45.7% were men and 90.6% were of White ethnicity. A total of 64,367 participants had gradable colour fundus photographs and 68,281 had gradable OCT scans in at least one eye. Retinal features suggestive of AMD and glaucoma were identified in 15,176 and 2184 participants, of whom 125 (0.8%) and 188 (8.6%), respectively, had a recorded diagnosis. Of 264 participants identified to have retinopathy with microaneurysms, 251 (95.1%) had either diabetes or hypertension.

Conclusions: this dataset represents a valuable addition to what is currently available in UKBB, providing important insights to both ocular and systemic health.

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Accepted/In Press date: 18 October 2022
e-pub ahead of print date: 3 November 2022
Published date: July 2023
Additional Information: Funding Information: the UK Biobank Eye and Vision Consortium is supported by grants from Moorfields Eye Charity, The NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, the Alcon Research Institute and the International Glaucoma Association (UK). ANW is supported by the Wellcome Trust (220558/Z/20/Z). KS is in receipt of a University College London Overseas Research Scholarship and is supported by grants from Fight for Sight (London) (1956A) and The Desmond Foundation. Fight for Sight (London) – ref: 1507 and 1508. Moorfields Eye Charity (Previous Moorfields Special Trustees ref: ST 15 11 E). The Macular Society (London). PJF is supported by an unrestricted grant from The Desmond Foundation. APK is supported by a UK Research and Innovation Future Leaders Fellowship, an Alcon Research Institute Young Investigator Award and a Lister Institute of Preventive Medicine Fellowship. A correction has been attached to this output located at https://www.nature.com/articles/s41433-022-02377-9 and https://doi.org/10.1038/s41433-022-02377-9
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Identifiers

Local EPrints ID: 473278
URI: http://eprints.soton.ac.uk/id/eprint/473278
DOI: doi:10.1038/s41433-022-02298-7
ISSN: 0950-222X
PURE UUID: 4b65f420-156a-48d1-b54b-64f65d4181a9
ORCID for Andrew J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305
ORCID for R. Carare: ORCID iD orcid.org/0000-0001-6458-3776
ORCID for S. Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for Andrew J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305
ORCID for J. Self: ORCID iD orcid.org/0000-0002-1030-9963
ORCID for I. Stratton: ORCID iD orcid.org/0000-0003-1172-7865

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Date deposited: 13 Jan 2023 17:40
Last modified: 18 Mar 2024 04:01

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Contributors

Author: Alasdair N. Warwick
Author: Katie Curran
Author: Barbra Hamill
Author: Kelsey Stuart
Author: Anthony P. Khawaja
Author: Paul J. Foster
Author: Andrew J. Lotery ORCID iD
Author: Michael Quinn
Author: Savita Madhusudhan
Author: Konstantinos Balaskas
Author: Tunde Peto
Author: N. Allen
Author: T. Aslam
Author: D. Atan
Author: S. Barman
Author: J. Barrett
Author: P. Bishop
Author: G. Black
Author: T. Braithwaite
Author: R. Carare ORCID iD
Author: U. Chakravarthy
Author: M. Chan
Author: S. Chua
Author: A. Day
Author: P. Desai
Author: B. Dhillon
Author: A. Dick
Author: A. Doney
Author: C. Egan
Author: S. Ennis ORCID iD
Author: P. Foster
Author: M. Fruttiger
Author: J. Gallacher
Author: D. Garway-Heath
Author: J. Gibson
Author: C. Hammond
Author: A. Hardcastle
Author: S. Harding
Author: Andrew J. Lotery ORCID iD
Author: T. Moore
Author: J. Morgan
Author: C. Owen
Author: P. Patel
Author: J. Self ORCID iD
Author: I. Stratton ORCID iD
Author: Z. Sun
Author: D. Thomas
Author: K. Williams
Author: C. Williams
Author: Y. Zheng
Corporate Author: UKBB Eye and Vision Consortium

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