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Which microbial factors really are important in Pseudomonas aeruginosa infections?

Which microbial factors really are important in Pseudomonas aeruginosa infections?
Which microbial factors really are important in Pseudomonas aeruginosa infections?
Over the last two decades, tens of millions of dollars have been invested in understanding virulence in the human pathogen, Pseudomonas aeruginosa. However, the top ‘hits’ obtained in a recent TnSeq analysis aimed at identifying those genes that are conditionally essential for infection did not include most of the known virulence factors identified in these earlier studies. Instead, it seems that P. aeruginosa faces metabolic challenges in vivo, and unless it can overcome these, it fails to thrive and is cleared from the host. In this review, we look at the kinds of metabolic pathways that the pathogen seems to find essential, and comment on how this knowledge might be therapeutically exploited.
1746-0913
1825-1836
Crousilles, Audrey
179a8411-28aa-4c71-9d41-a89560396030
Maunders, Eve
41e9a0e8-13ff-43eb-8bbf-9c3aa9090de0
Bartlett, Sean
06d3b814-b562-4f44-8dff-43e29a939340
Fan, Catherine
28ff90c0-8ccb-4f3c-b557-710235db8031
Ukor, Emem-Fong
cb515709-c858-420f-9e69-8081df585f35
Abdelhamid, Yassmin
1238c87f-934e-4907-8ca8-b5fef53ba7d8
Baker, Ysobel
4fceec1f-89ed-4a32-a753-8967daf6763a
Floto, R Andres
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Spring, David R.
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Welch, Martin
ca64057d-4378-4cf4-9bc4-7dfd512954c4
Crousilles, Audrey
179a8411-28aa-4c71-9d41-a89560396030
Maunders, Eve
41e9a0e8-13ff-43eb-8bbf-9c3aa9090de0
Bartlett, Sean
06d3b814-b562-4f44-8dff-43e29a939340
Fan, Catherine
28ff90c0-8ccb-4f3c-b557-710235db8031
Ukor, Emem-Fong
cb515709-c858-420f-9e69-8081df585f35
Abdelhamid, Yassmin
1238c87f-934e-4907-8ca8-b5fef53ba7d8
Baker, Ysobel
4fceec1f-89ed-4a32-a753-8967daf6763a
Floto, R Andres
79ab6e97-aee4-441c-81ba-8d829c057043
Spring, David R.
5e03dd4b-9d92-4169-aab1-8da241e02a3d
Welch, Martin
ca64057d-4378-4cf4-9bc4-7dfd512954c4

Crousilles, Audrey, Maunders, Eve, Bartlett, Sean, Fan, Catherine, Ukor, Emem-Fong, Abdelhamid, Yassmin, Baker, Ysobel, Floto, R Andres, Spring, David R. and Welch, Martin (2015) Which microbial factors really are important in Pseudomonas aeruginosa infections? Future Microbiology, 10 (11), 1825-1836. (doi:10.2217/fmb.15.100).

Record type: Article

Abstract

Over the last two decades, tens of millions of dollars have been invested in understanding virulence in the human pathogen, Pseudomonas aeruginosa. However, the top ‘hits’ obtained in a recent TnSeq analysis aimed at identifying those genes that are conditionally essential for infection did not include most of the known virulence factors identified in these earlier studies. Instead, it seems that P. aeruginosa faces metabolic challenges in vivo, and unless it can overcome these, it fails to thrive and is cleared from the host. In this review, we look at the kinds of metabolic pathways that the pathogen seems to find essential, and comment on how this knowledge might be therapeutically exploited.

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Published date: 30 October 2015

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Local EPrints ID: 473382
URI: http://eprints.soton.ac.uk/id/eprint/473382
ISSN: 1746-0913
PURE UUID: ecd373a2-f13a-442b-9c27-926bad972c76
ORCID for Ysobel Baker: ORCID iD orcid.org/0000-0002-0266-771X

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Date deposited: 17 Jan 2023 17:37
Last modified: 17 Mar 2024 04:17

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Contributors

Author: Audrey Crousilles
Author: Eve Maunders
Author: Sean Bartlett
Author: Catherine Fan
Author: Emem-Fong Ukor
Author: Yassmin Abdelhamid
Author: Ysobel Baker ORCID iD
Author: R Andres Floto
Author: David R. Spring
Author: Martin Welch

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