Longitudinal assessment of calcium and magnesium levels in women with preeclampsia
Longitudinal assessment of calcium and magnesium levels in women with preeclampsia
The present study reports the levels of maternal serum calcium and magnesium from early pregnancy until delivery, along with cord levels, in women who developed preeclampsia (PE) and compares them with those without PE. A total of 324 pregnant women (216 non-PE and 108 PE women) were included in this retrospective case-control study of prospectively collected data nested in an observational cohort study. Maternal blood was collected at 4 time points during pregnancy (V1 = 11-14 weeks, V2 = 18-22 weeks, V3 = 26-28 weeks, and V4 = at delivery) and umbilical cord blood at delivery. Independent t tests were used to compare calcium, magnesium, and their ratio between two groups, and their associations with PE were studied using regression models. Calcium levels were similar between groups at all time points. Magnesium levels were lower (p = 0.021) at V2 in PE group as compared with non-PE group. Maternal calcium and magnesium levels were negatively associated, with blood pressure in early pregnancy. In fully adjusted logistic regression analysis, lower magnesium levels were associated with an increased risk of PE at V2 (OR 0.25 [95% CI 0.07, 0.94] p = 0.04). Lower magnesium in mid-pregnancy was associated with higher risk of PE. These changes were observed before the diagnosis of PE, thereby suggesting that they may have a role in the etiology of PE.
Blood pressure, Calcium, Magnesium, Preeclampsia, Prospective study
Wadhwani, Nisha
55a4b1e7-16fd-49fe-a8a4-2c5458dfbf95
Dangat, Kamini
6f67775d-72e6-4dac-baa1-39e300a18918
Randhir, Karuna
1a71f1e4-0a52-4986-87bb-d3a20c09ecbb
Poddar, Anupam
21556107-cd07-4cb6-845e-6d048a0e4be1
Joshi, Prachi
70468346-3333-4016-9980-838c8a8a5ded
Pisal, Hemlata
45db3cfe-4de3-4fec-a3c4-ba4c0d245f2b
Kadam, Vrushali
1a726a6a-ba7f-4a78-bc09-7acb5b48b76a
Bakshi, Ravleen
d760b774-af29-4e71-ad2a-2339a783ec60
Chandhiok, Nomita
796fd51a-e159-43b6-b71d-e3ed35767ab3
Lalwani, Sanjay
95b1df54-f8f9-417c-ac49-e4651a6e6a8d
Mehendale, Savita
60b23ecf-176c-4887-9736-73c6f2b1813e
Wagh, Girija
b3c1c7f3-5ee6-45d0-9c62-ed914739295d
Gupte, Sanjay
a912ce2c-a6f0-46fb-b5c6-398db8eadfd7
Sachdev, Harshpal Singh
2fca6c24-2750-47b4-b675-7c7da6e5c987
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Joshi, Sadhana
40f08f3b-bfdf-4b1b-8f0e-5078bb122de2
Wadhwani, Nisha
55a4b1e7-16fd-49fe-a8a4-2c5458dfbf95
Dangat, Kamini
6f67775d-72e6-4dac-baa1-39e300a18918
Randhir, Karuna
1a71f1e4-0a52-4986-87bb-d3a20c09ecbb
Poddar, Anupam
21556107-cd07-4cb6-845e-6d048a0e4be1
Joshi, Prachi
70468346-3333-4016-9980-838c8a8a5ded
Pisal, Hemlata
45db3cfe-4de3-4fec-a3c4-ba4c0d245f2b
Kadam, Vrushali
1a726a6a-ba7f-4a78-bc09-7acb5b48b76a
Bakshi, Ravleen
d760b774-af29-4e71-ad2a-2339a783ec60
Chandhiok, Nomita
796fd51a-e159-43b6-b71d-e3ed35767ab3
Lalwani, Sanjay
95b1df54-f8f9-417c-ac49-e4651a6e6a8d
Mehendale, Savita
60b23ecf-176c-4887-9736-73c6f2b1813e
Wagh, Girija
b3c1c7f3-5ee6-45d0-9c62-ed914739295d
Gupte, Sanjay
a912ce2c-a6f0-46fb-b5c6-398db8eadfd7
Sachdev, Harshpal Singh
2fca6c24-2750-47b4-b675-7c7da6e5c987
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Joshi, Sadhana
40f08f3b-bfdf-4b1b-8f0e-5078bb122de2
Wadhwani, Nisha, Dangat, Kamini, Randhir, Karuna, Poddar, Anupam, Joshi, Prachi, Pisal, Hemlata, Kadam, Vrushali, Bakshi, Ravleen, Chandhiok, Nomita, Lalwani, Sanjay, Mehendale, Savita, Wagh, Girija, Gupte, Sanjay, Sachdev, Harshpal Singh, Fall, Caroline and Joshi, Sadhana
(2022)
Longitudinal assessment of calcium and magnesium levels in women with preeclampsia.
Biological trace element research.
(doi:10.1007/s12011-022-03440-y).
Abstract
The present study reports the levels of maternal serum calcium and magnesium from early pregnancy until delivery, along with cord levels, in women who developed preeclampsia (PE) and compares them with those without PE. A total of 324 pregnant women (216 non-PE and 108 PE women) were included in this retrospective case-control study of prospectively collected data nested in an observational cohort study. Maternal blood was collected at 4 time points during pregnancy (V1 = 11-14 weeks, V2 = 18-22 weeks, V3 = 26-28 weeks, and V4 = at delivery) and umbilical cord blood at delivery. Independent t tests were used to compare calcium, magnesium, and their ratio between two groups, and their associations with PE were studied using regression models. Calcium levels were similar between groups at all time points. Magnesium levels were lower (p = 0.021) at V2 in PE group as compared with non-PE group. Maternal calcium and magnesium levels were negatively associated, with blood pressure in early pregnancy. In fully adjusted logistic regression analysis, lower magnesium levels were associated with an increased risk of PE at V2 (OR 0.25 [95% CI 0.07, 0.94] p = 0.04). Lower magnesium in mid-pregnancy was associated with higher risk of PE. These changes were observed before the diagnosis of PE, thereby suggesting that they may have a role in the etiology of PE.
Text
REVAMP study Calcium Magnesium accepted version
- Accepted Manuscript
Text
s12011-022-03440-y
- Version of Record
Restricted to Repository staff only
Request a copy
More information
Accepted/In Press date: 3 October 2022
e-pub ahead of print date: 10 October 2022
Additional Information:
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Keywords:
Blood pressure, Calcium, Magnesium, Preeclampsia, Prospective study
Identifiers
Local EPrints ID: 473431
URI: http://eprints.soton.ac.uk/id/eprint/473431
ISSN: 0163-4984
PURE UUID: 99e2ace8-3cb6-4b60-9691-897f4266801a
Catalogue record
Date deposited: 18 Jan 2023 17:31
Last modified: 17 Mar 2024 07:34
Export record
Altmetrics
Contributors
Author:
Nisha Wadhwani
Author:
Kamini Dangat
Author:
Karuna Randhir
Author:
Anupam Poddar
Author:
Prachi Joshi
Author:
Hemlata Pisal
Author:
Vrushali Kadam
Author:
Ravleen Bakshi
Author:
Nomita Chandhiok
Author:
Sanjay Lalwani
Author:
Savita Mehendale
Author:
Girija Wagh
Author:
Sanjay Gupte
Author:
Harshpal Singh Sachdev
Author:
Sadhana Joshi
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
