Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

e-pub ahead of print date: 25 November 2022

Additional Information: Funding Information: This work was supported by the European Union’s Horizon 2020 research and innovation program EAVI2020 under grant agreement no. 681137, as well as the HIV Vaccine Research and Design (HIVRAD) program (P01 AI110657) (A.B.W. and R.W.S). Furthermore, this work was supported, in whole or in part, by the Collaboration for AIDS Vaccine Discovery (CAVD) grants OPP1115782, OPP1132237, INV-002022, funded by the Bill and Melinda Gates Foundation. Under the grant conditions of the Foundation, a Creative Commons Attribution 4.0 Generic License has already been assigned to the Author Accepted Manuscript version that might arise from this submission. R.W.S. is a recipient of a Vici fellowship from the Netherlands Organization for Scientific Research (NWO). M.J.v.G. is supported by an amfAR Mathilde Krim Fellowships in Basic Biomedical Research grant number 109514-61-RKVA and the 2017 AMC Fellowship. Al.A. is supported by amfAR Mathilde Krim Fellowship in Biomedical Research no. 110182-69-RKVA. The neutralization assays performed at Duke University were supported by NIAID-NIH (HHSN272201800004C). The Infectious Disease Models and Innovative Therapies research infrastructure (IDMIT) is supported by the “Program Investissements d’Avenir” (PIA), managed by the ANR under references ANR-11-INBS-0008. The glycopeptide analysis was supported by the CAVD grant INV-008352/OPP1153692 funded by the Bill and Melinda Gates Foundation (M.C.). We are grateful to the staff of IDMIT, particularly to C. Joubert, R. Ho Tsong Fang, B. Delache, S. Langlois, E. Burban, M. Potier, N. Dhooge, J.-M. Robert, M. Barendi, J. Dinh, E. Guyon, S. Keyser and I. Mangeot. G.S., R.W.S, and M.J.v.G. received charitable donations from Fondation Dormeur, Vaduz, for instruments supporting the research of this study. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022, The Author(s).

Local EPrints ID: 473553

URI: http://eprints.soton.ac.uk/id/eprint/473553

DOI: doi:10.1038/s41541-022-00576-9

ISSN: 2059-0105

PURE UUID: 43986091-2a3e-4de8-bf2e-c24a994b7acf

ORCID for J. D. Allen: orcid.org/0000-0003-2547-968X

ORCID for H. Chawla: orcid.org/0000-0001-9828-6593

ORCID for M. Crispin: orcid.org/0000-0002-1072-2694

Date deposited: 23 Jan 2023 17:48

Last modified: 18 Mar 2024 04:03