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Potential human transmission of amyloid β pathology: surveillance and risks

Potential human transmission of amyloid β pathology: surveillance and risks
Potential human transmission of amyloid β pathology: surveillance and risks

Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, convincing evidence for human iatrogenic transmission only exists for prions and amyloid β after systemic injections of contaminated growth hormone extracts or dura mater grafts derived from cadavers. Even though these procedures are now obsolete, some reports raise the possibility of iatrogenic transmission of amyloid β through putatively contaminated neurosurgical equipment. Iatrogenic transmission of amyloid β might lead to amyloid deposition in the brain parenchyma and blood vessel walls, potentially resulting in cerebral amyloid angiopathy after several decades. Cerebral amyloid angiopathy can cause life-threatening brain haemorrhages; yet, there is no proof that the transmission of amyloid β can also lead to Alzheimer's dementia. Large, long-term epidemiological studies and sensitive, cost-efficient tools to detect amyloid are needed to better understand any potential routes of amyloid β transmission and to clarify whether other similar proteopathic seeds, such as tau or α-synuclein, can also be transferred iatrogenically.

1474-4422
872-878
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Helmy, Adel
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Jucker, Mathias
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Lemmens, Robin
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Love, Seth
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Mead, Simon
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Smith, Colin
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van den Burg, Peter
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Vandekerckhove, Philippe
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Walton, Clare
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Zaaijer, Hans L.
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Zetterberg, Henrik
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De Strooper, Bart
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Lauwers, Elsa
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Brandner, Sebastian
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Collinge, John
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Helmy, Adel
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Ivinson, Adrian J.
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Jucker, Mathias
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Knight, Richard
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Lemmens, Robin
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Love, Seth
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Mead, Simon
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Perry, V. Hugh
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Pickett, James
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Poppy, Guy
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Radford, Sheena E.
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Rousseau, Frederic
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Routledge, Carol
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Schiavo, Giampietro
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Schymkowitz, Joost
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Smith, Colin
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Thal, Dietmar R.
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Theys, Tom
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Tiberghien, Pierre
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van den Burg, Peter
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Vandekerckhove, Philippe
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Walton, Clare
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Zaaijer, Hans L.
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Zetterberg, Henrik
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De Strooper, Bart
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Lauwers, Elsa, Lalli, Giovanna, Brandner, Sebastian, Collinge, John, Compernolle, Veerle, Duyckaerts, Charles, Edgren, Gustaf, Haïk, Stéphane, Hardy, John, Helmy, Adel, Ivinson, Adrian J., Jaunmuktane, Zane, Jucker, Mathias, Knight, Richard, Lemmens, Robin, Lin, I. Chun, Love, Seth, Mead, Simon, Perry, V. Hugh, Pickett, James, Poppy, Guy, Radford, Sheena E., Rousseau, Frederic, Routledge, Carol, Schiavo, Giampietro, Schymkowitz, Joost, Selkoe, Dennis J., Smith, Colin, Thal, Dietmar R., Theys, Tom, Tiberghien, Pierre, van den Burg, Peter, Vandekerckhove, Philippe, Walton, Clare, Zaaijer, Hans L., Zetterberg, Henrik and De Strooper, Bart (2020) Potential human transmission of amyloid β pathology: surveillance and risks. The Lancet Neurology, 19 (10), 872-878. (doi:10.1016/S1474-4422(20)30238-6).

Record type: Review

Abstract

Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, convincing evidence for human iatrogenic transmission only exists for prions and amyloid β after systemic injections of contaminated growth hormone extracts or dura mater grafts derived from cadavers. Even though these procedures are now obsolete, some reports raise the possibility of iatrogenic transmission of amyloid β through putatively contaminated neurosurgical equipment. Iatrogenic transmission of amyloid β might lead to amyloid deposition in the brain parenchyma and blood vessel walls, potentially resulting in cerebral amyloid angiopathy after several decades. Cerebral amyloid angiopathy can cause life-threatening brain haemorrhages; yet, there is no proof that the transmission of amyloid β can also lead to Alzheimer's dementia. Large, long-term epidemiological studies and sensitive, cost-efficient tools to detect amyloid are needed to better understand any potential routes of amyloid β transmission and to clarify whether other similar proteopathic seeds, such as tau or α-synuclein, can also be transferred iatrogenically.

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More information

Published date: 1 October 2020
Additional Information: Funding Information: We thank the UK Dementia Research Institute (which receives funding from the UK Medical Research Council, the Alzheimer's Society, and Alzheimer's Research UK), the Belgian Red Cross, the European Blood Alliance, the Institut du Cerveau et de la Moelle Epinière, and Mission Lucidity for co-organising and funding the Amyloid Transmissibility Workshop that was held in London, UK, on Oct 7–8, 2019, and led to the present Personal View. Funding Information: AH reports personal fees from Pressura Neuro, outside the submitted work. AJI is a consultant for Sun Pharma Advanced Research Company. CD declares, for work in histopathology assessments, their institution (the Paris Brain Institute) received a remuneration from Sanofi. DJS is a director and consultant of Prothena Biosciences. DRT reports grants from Fonds Wetenschappelijk Onderzoek during the conduct of the study, non-financial support from GE Healthcare, Novartis, and Probiodrug, grants from Janssen Pharmaceutical companies, travel reimbursement for a meeting from UCB, outside the submitted work, and speakers' honoraria or travel reimbursement for invited talks from Novartis (Basel, Switzerland), GE-Healthcare (Amersham, UK), and UCB (Braine-l'Alleud, Belgium). GP is the chief scientific adviser to the Food Standards Agency and the Director of the UK Research and Innovation Strategic Priorities Fund programme on a food systems approach for healthy people and a healthy planet, and declares that he contributed to this paper as a university professor and not in the capacity of a government adviser or director. GS is a consultant for Fastox, and reports grants from the Wellcome Trust, the EU's Horizon 2020 programme, and the UK Dementia Research Institute, outside the submitted work. HZ has served on scientific advisory boards for Denali, Roche Diagnostics, Wave, Samumed, and CogRx, has given lectures at symposia sponsored by Fujirebio, Alzecure, and Biogen, and reports financial support from the UK Dementia Research Institute, outside the submitted work. JC reports a financial relationship with D-Gen, outside the submitted work. BDS reports financial support from the UK Dementia Research Institute, outside the submitted work. JH reports grants from the Medical Research Council, and financial support from the UK Dementia Research Institute, the Dolby Family Fund, and the National Institute for Health Research University College London Hospitals Biomedical Research Centre, outside the submitted work. JS reports that the Switch Laboratory is supported by grants from the EU's Horizon 2020 programme (European Research Council), the Flanders institute for biotechnology (Vlaams Instituut voor Biotechnologie), KU Leuven, the Industrial Research Council of KU Leuven, Funds for Scientific Research Flanders (Fonds Wetenschappelijk Onderzoek), and Hercules Stichting, outside the submitted work. FR reports that the Switch Laboratory is supported by grants from the EU's Horizon 2020 programme (European Research Council), the Flanders institute for biotechnology (Vlaams Instituut voor Biotechnologie), KU Leuven, the Industrial Research Council of KU Leuven, Funds for Scientific Research Flanders (Fonds Wetenschappelijk Onderzoek), and Hercules Stichting, outside the submitted work. MJ served on a scientific advisory board for Roche (Basel), outside the submitted work. PT is employed by the French Transfusion Public Service (Etablissement Français du Sang) and is in charge of collecting, preparing, and issuing labile blood products in France. SB reports financial support from the UK Department of Health's National Institute for Health Research Biomedical Research Centre's funding scheme, outside the submitted work. ZJ reports financial support from the UK Department of Health's National Institute for Health Research Biomedical Research Centre's funding scheme, outside the submitted work. SH reports grants from MedDay Pharmaceuticals, LFB Biomedicaments, and the Institut de Recherche Servier, outside the submitted work. All other authors declare no competing interests. Publisher Copyright: © 2020 Elsevier Ltd

Identifiers

Local EPrints ID: 473571
URI: http://eprints.soton.ac.uk/id/eprint/473571
ISSN: 1474-4422
PURE UUID: 74b7ce8d-51f5-4c30-89f2-9544bd33b916

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Date deposited: 23 Jan 2023 18:19
Last modified: 17 Mar 2024 13:14

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Contributors

Author: Elsa Lauwers
Author: Giovanna Lalli
Author: Sebastian Brandner
Author: John Collinge
Author: Veerle Compernolle
Author: Charles Duyckaerts
Author: Gustaf Edgren
Author: Stéphane Haïk
Author: John Hardy
Author: Adel Helmy
Author: Adrian J. Ivinson
Author: Zane Jaunmuktane
Author: Mathias Jucker
Author: Richard Knight
Author: Robin Lemmens
Author: I. Chun Lin
Author: Seth Love
Author: Simon Mead
Author: V. Hugh Perry
Author: James Pickett
Author: Guy Poppy
Author: Sheena E. Radford
Author: Frederic Rousseau
Author: Carol Routledge
Author: Giampietro Schiavo
Author: Joost Schymkowitz
Author: Dennis J. Selkoe
Author: Colin Smith
Author: Dietmar R. Thal
Author: Tom Theys
Author: Pierre Tiberghien
Author: Peter van den Burg
Author: Philippe Vandekerckhove
Author: Clare Walton
Author: Hans L. Zaaijer
Author: Henrik Zetterberg
Author: Bart De Strooper

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