Molecular boronic acid-based saccharide sensors
Molecular boronic acid-based saccharide sensors
Boronic acids can reversibly bind diols, a molecular feature that is ubiquitous within saccharides, leading to their use in the design and implementation of sensors for numerous saccharide species. There is a growing understanding of the importance of saccharides in many biological processes and systems; while saccharide or carbohydrate sensing in medicine is most often associated with detection of glucose in diabetes patients, saccharides have proven to be relevant in a range of disease states. Herein the relevance of carbohydrate sensing for biomedical applications is explored, and this review seeks to outline how the complexity of saccharides presents a challenge for the development of selective sensors and describes efforts that have been made to understand the underpinning fluorescence and binding mechanisms of these systems, before outlining examples of how researchers have used this knowledge to develop ever more selective receptors.
Carbohydrates, fluorescence, organic compounds, Receptors, sensors
1508–1528
Williams, George
26810522-92ef-4b61-a766-582bf15be280
Kedge, Jonathan L.
57f4c4ae-fd3c-4737-a734-1f1a137f853c
Fossey, John S.
e080d7fe-9246-4d09-b598-e516f27168fd
Williams, George
26810522-92ef-4b61-a766-582bf15be280
Kedge, Jonathan L.
57f4c4ae-fd3c-4737-a734-1f1a137f853c
Fossey, John S.
e080d7fe-9246-4d09-b598-e516f27168fd
Williams, George, Kedge, Jonathan L. and Fossey, John S.
(2021)
Molecular boronic acid-based saccharide sensors.
ACS Sensors, 6 (4), .
(doi:10.1021/acssensors.1c00462).
Abstract
Boronic acids can reversibly bind diols, a molecular feature that is ubiquitous within saccharides, leading to their use in the design and implementation of sensors for numerous saccharide species. There is a growing understanding of the importance of saccharides in many biological processes and systems; while saccharide or carbohydrate sensing in medicine is most often associated with detection of glucose in diabetes patients, saccharides have proven to be relevant in a range of disease states. Herein the relevance of carbohydrate sensing for biomedical applications is explored, and this review seeks to outline how the complexity of saccharides presents a challenge for the development of selective sensors and describes efforts that have been made to understand the underpinning fluorescence and binding mechanisms of these systems, before outlining examples of how researchers have used this knowledge to develop ever more selective receptors.
Text
acssensors.1c00462
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More information
Accepted/In Press date: 30 March 2021
e-pub ahead of print date: 12 April 2021
Keywords:
Carbohydrates, fluorescence, organic compounds, Receptors, sensors
Identifiers
Local EPrints ID: 473585
URI: http://eprints.soton.ac.uk/id/eprint/473585
ISSN: 2379-3694
PURE UUID: a96f915b-ebdc-4c0c-b526-826b16900bcf
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Date deposited: 24 Jan 2023 17:35
Last modified: 17 Mar 2024 04:17
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Contributors
Author:
George Williams
Author:
Jonathan L. Kedge
Author:
John S. Fossey
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