Development of a multifunctional benzophenone linker for peptide stapling and photoaffinity labelling
Development of a multifunctional benzophenone linker for peptide stapling and photoaffinity labelling
Three functionalities, one linker: A novel multifunctional linker was designed for peptide stapling and photoaffinity labelling. This approach uses a benzophenone moiety for crosslinking and an additional alkyne handle for subsequent pull-down assays. The alternative labelling technique was applied to the p53/MDM2 interaction as proof of principle.
689-692
Wu, Yuteng
17b6ff7d-b15a-40fd-8d87-35f0b7ff8cf0
Olsen, Lasse B.
1b373226-e0b3-4c14-a7ee-a31bc11f6830
Lau, Yu Heng
3a8fdbfe-7e07-488c-b5bc-644645a3fe3a
Jensen, Claus Hatt
6b553295-7be1-44c8-a0a7-9709659e8a40
Rossmann, Maxim
79dc0455-4269-4441-ab9e-d6fbb9703c5d
Baker, Ysobel
4fceec1f-89ed-4a32-a753-8967daf6763a
Sore, Hannah F.
aefb40f7-43fd-450c-8151-2e98a1552f45
Collins, Súil
4b128495-1a6e-4982-b866-5a4fc6fe2944
Spring, David R.
5e03dd4b-9d92-4169-aab1-8da241e02a3d
16 March 2016
Wu, Yuteng
17b6ff7d-b15a-40fd-8d87-35f0b7ff8cf0
Olsen, Lasse B.
1b373226-e0b3-4c14-a7ee-a31bc11f6830
Lau, Yu Heng
3a8fdbfe-7e07-488c-b5bc-644645a3fe3a
Jensen, Claus Hatt
6b553295-7be1-44c8-a0a7-9709659e8a40
Rossmann, Maxim
79dc0455-4269-4441-ab9e-d6fbb9703c5d
Baker, Ysobel
4fceec1f-89ed-4a32-a753-8967daf6763a
Sore, Hannah F.
aefb40f7-43fd-450c-8151-2e98a1552f45
Collins, Súil
4b128495-1a6e-4982-b866-5a4fc6fe2944
Spring, David R.
5e03dd4b-9d92-4169-aab1-8da241e02a3d
Wu, Yuteng, Olsen, Lasse B., Lau, Yu Heng, Jensen, Claus Hatt, Rossmann, Maxim, Baker, Ysobel, Sore, Hannah F., Collins, Súil and Spring, David R.
(2016)
Development of a multifunctional benzophenone linker for peptide stapling and photoaffinity labelling.
ChemBioChem, 17 (8), .
(doi:10.1002/cbic.201500648).
Abstract
Three functionalities, one linker: A novel multifunctional linker was designed for peptide stapling and photoaffinity labelling. This approach uses a benzophenone moiety for crosslinking and an additional alkyne handle for subsequent pull-down assays. The alternative labelling technique was applied to the p53/MDM2 interaction as proof of principle.
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e-pub ahead of print date: 26 February 2016
Published date: 16 March 2016
Identifiers
Local EPrints ID: 473696
URI: http://eprints.soton.ac.uk/id/eprint/473696
ISSN: 1439-4227
PURE UUID: 8e924210-baf6-4ce2-b0b2-17422e38d64d
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Date deposited: 27 Jan 2023 17:52
Last modified: 17 Mar 2024 04:17
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Contributors
Author:
Yuteng Wu
Author:
Lasse B. Olsen
Author:
Yu Heng Lau
Author:
Claus Hatt Jensen
Author:
Maxim Rossmann
Author:
Ysobel Baker
Author:
Hannah F. Sore
Author:
Súil Collins
Author:
David R. Spring
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