In silico design of recombinant chimera T cell peptide epitope vaccines for visceral Leishmaniasis
In silico design of recombinant chimera T cell peptide epitope vaccines for visceral Leishmaniasis
Visceral leishmaniasis (VL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. Systemic VL is fatal if untreated and there are no prophylactic human vaccines available. Several studies suggest that Th1 cell-mediated immunity plays a major role in protecting against VL. In this chapter we describe a method for designing recombinant chimera vaccines in silico based on the prediction of T cell epitopes within protein antigens identified as potential protective immunogens. Development of a recombinant chimera protein (RCP) vaccine using T cell epitope peptides identified from four Leishmania proteins is used as an exemplar of this method.
463-480
Machado, Amanda Sanchez
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Martins, Vivian Tamietti
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Humbert, Maria Victoria
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Christodoulides, Myron
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Coelho, Eduardo Antonio Ferraz
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Machado, Amanda Sanchez
995b6d7e-c1f0-45fb-9612-dc23e059eb6a
Martins, Vivian Tamietti
ce6b501c-77e2-4bed-a3a0-b9f2be780def
Humbert, Maria Victoria
82134d25-24b8-4fdd-bd1c-461683b5322e
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Coelho, Eduardo Antonio Ferraz
5c523e55-2068-434c-a573-099ecedccb87
Machado, Amanda Sanchez, Martins, Vivian Tamietti, Humbert, Maria Victoria, Christodoulides, Myron and Coelho, Eduardo Antonio Ferraz
(2021)
In silico design of recombinant chimera T cell peptide epitope vaccines for visceral Leishmaniasis.
In,
Vaccine Design: Methods and Protocols Volume 1: Vaccines for Human Diseases.
(Methods in Molecular Biology, 1)
2 ed.
.
(doi:10.1007/978-1-0716-1884-4_24).
Record type:
Book Section
Abstract
Visceral leishmaniasis (VL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. Systemic VL is fatal if untreated and there are no prophylactic human vaccines available. Several studies suggest that Th1 cell-mediated immunity plays a major role in protecting against VL. In this chapter we describe a method for designing recombinant chimera vaccines in silico based on the prediction of T cell epitopes within protein antigens identified as potential protective immunogens. Development of a recombinant chimera protein (RCP) vaccine using T cell epitope peptides identified from four Leishmania proteins is used as an exemplar of this method.
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e-pub ahead of print date: 17 December 2021
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Local EPrints ID: 473906
URI: http://eprints.soton.ac.uk/id/eprint/473906
ISSN: 1064-3745
PURE UUID: 88e4d7aa-d7db-4701-b41d-a0973616fd09
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Date deposited: 03 Feb 2023 17:32
Last modified: 17 Mar 2024 03:35
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Author:
Amanda Sanchez Machado
Author:
Vivian Tamietti Martins
Author:
Maria Victoria Humbert
Author:
Eduardo Antonio Ferraz Coelho
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