Advancements in antimicrobial nanoscale materials and self-assembling systems
Advancements in antimicrobial nanoscale materials and self-assembling systems
Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 and 2050. Already heralded as one of the greatest threats to human health, the onset of the coronavirus pandemic has accelerated the prevalence of antimicrobial resistant bacterial infections due to factors including increased global antibiotic/antimicrobial use. Thus an urgent need for novel therapeutics to combat what some have termed the ‘silent pandemic’ is evident. This review acts as a repository of research and an overview of the novel therapeutic strategies being developed to overcome antimicrobial resistance, with a focus on self-assembling systems and nanoscale materials. The fundamental mechanisms of action, as well as the key advantages and disadvantages of each system are discussed, and attention is drawn to key examples within each field. As a result, this review provides a guide to the further design and development of antimicrobial systems, and outlines the interdisciplinary techniques required to translate this fundamental research towards the clinic.
8696-8755
Doolan, Jack A.
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Williams, George T.
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Hilton, Kira L. F.
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Chaudhari, Rajas
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Fossey, John S.
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Goult, Benjamin T.
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Hiscock, Jennifer
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Doolan, Jack A.
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Williams, George T.
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Hilton, Kira L. F.
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Chaudhari, Rajas
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Fossey, John S.
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Goult, Benjamin T.
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Hiscock, Jennifer
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Doolan, Jack A., Williams, George T., Hilton, Kira L. F., Chaudhari, Rajas, Fossey, John S., Goult, Benjamin T. and Hiscock, Jennifer
(2022)
Advancements in antimicrobial nanoscale materials and self-assembling systems.
Chemical Society Reviews, 51 (20), .
(doi:10.1039/D1CS00915J).
Abstract
Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 and 2050. Already heralded as one of the greatest threats to human health, the onset of the coronavirus pandemic has accelerated the prevalence of antimicrobial resistant bacterial infections due to factors including increased global antibiotic/antimicrobial use. Thus an urgent need for novel therapeutics to combat what some have termed the ‘silent pandemic’ is evident. This review acts as a repository of research and an overview of the novel therapeutic strategies being developed to overcome antimicrobial resistance, with a focus on self-assembling systems and nanoscale materials. The fundamental mechanisms of action, as well as the key advantages and disadvantages of each system are discussed, and attention is drawn to key examples within each field. As a result, this review provides a guide to the further design and development of antimicrobial systems, and outlines the interdisciplinary techniques required to translate this fundamental research towards the clinic.
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d1cs00915j
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e-pub ahead of print date: 3 October 2022
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Acknowledgements:
JAD and KLFH would like to thank the University of Kent for funding. GTW would like to thank the University of Birmingham and Cancer Research UK for ongoing support (Pioneer Award 26212). JRH would like to thank the UKRI for the funding of her Future Leaders Fellowship (MR/T020415/1). BTG would like to acknowledge BBSRC (BB/S007245/1) and Cancer Research UK Program grant (DRCRPG-May21) for
funding.
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Local EPrints ID: 474143
URI: http://eprints.soton.ac.uk/id/eprint/474143
ISSN: 0306-0012
PURE UUID: dbca260c-fa6c-492f-be1f-831dcc21dcba
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Date deposited: 14 Feb 2023 17:40
Last modified: 17 Mar 2024 04:17
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Contributors
Author:
Jack A. Doolan
Author:
George T. Williams
Author:
Kira L. F. Hilton
Author:
Rajas Chaudhari
Author:
John S. Fossey
Author:
Benjamin T. Goult
Author:
Jennifer Hiscock
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