Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial

e-pub ahead of print date: 22 December 2022

Published date: 28 January 2023

Additional Information: Funding Information: This study was funded by the NIHR (NIHR135366). KH and SP are co-investigators on this grant, and DMI was a co-applicant. CCB received support as an NIHR senior investigator, from the NIHR Community Healthcare Medtech and In-Vitro Diagnostics Co-operative, and from the NIHR Health Protection Research Unit on Health Care Associated Infections and Antimicrobial Resistance. FDRH is part-funded by the NIHR Applied Research Collaboration and the NIHR Community Healthcare Medtech and In-Vitro Diagnostics Co-operative. GH is funded by an NIHR advanced fellowship and by the NIHR Community Healthcare Medtech and In-Vitro Diagnostics Co-operative (MIC). JD is funded by the Wellcome Trust PhD programme for primary care clinicians (216421/Z/19/Z). SP receives support as an NIHR senior investigator (NF-SI-0616-10103) and from the UK NIHR Applied Research Collaboration Oxford and Thames Valley. OAG receives funding from the European Clinical Research Alliance on Infectious Diseases (project number 101046109). JB receives supports as an NIHR senior investigator and from the University College London Hospitals NIHR Biomedical Research Centre. JFS received a UK Medical Research Council project grant (MR/X004724/1) that contributed to the design of the virology study. HA is supported by an NIHR Advanced Fellowship funded by Health and Care Research Wales. JFS has received research grants from the UK Medical Research Council (MR/X004724/1, MR/W015560/1), the Wellcome Trust, NIHR, and the Drugs for Neglected Diseases Initiative, all of which were paid to his institution. OvH has received an NIHR Development and Skills Personal Award. T-AM reports grant funding from Cardiff University through an NIHR award to the University of Oxford. NF reports receiving NIHR grant funding. ML and PL report funding from the NIHR for PANORAMIC. We thank all participants in the study, all participating general practices, NHS COVID-19 treatment services, and other health and social care organisations supporting the trial for their work and support, our patient and public involvement contributors, the trial steering and data monitoring and safety committees, primary care colleagues in the NIHR Clinical Research Network (lead network: Thames Valley and South Midlands), Health and Care Research Wales, NHS Research Scotland, the Health and Social Care Board in Northern Ireland, the NIHR, and the Therapeutics Task Force, NHS DigiTrials, the Intensive Care National Audit and Research Centre, Public Health Scotland, the National Records Service of Scotland, the Secure Anonymised Information Linkage at the University of Swansea, and Health and Social Care Northern Ireland. The views expressed in this Article are the authors' and not necessarily those of the NIHR or the Department of Health and Social Care. Funding Information: This study was funded by the NIHR (NIHR135366). KH and SP are co-investigators on this grant, and DMI was a co-applicant. CCB received support as an NIHR senior investigator, from the NIHR Community Healthcare Medtech and In-Vitro Diagnostics Co-operative, and from the NIHR Health Protection Research Unit on Health Care Associated Infections and Antimicrobial Resistance. FDRH is part-funded by the NIHR Applied Research Collaboration and the NIHR Community Healthcare Medtech and In-Vitro Diagnostics Co-operative. GH is funded by an NIHR advanced fellowship and by the NIHR Community Healthcare Medtech and In-Vitro Diagnostics Co-operative (MIC). JD is funded by the Wellcome Trust PhD programme for primary care clinicians (216421/Z/19/Z). SP receives support as an NIHR senior investigator (NF-SI-0616-10103) and from the UK NIHR Applied Research Collaboration Oxford and Thames Valley. OAG receives funding from the European Clinical Research Alliance on Infectious Diseases (project number 101046109). JB receives supports as an NIHR senior investigator and from the University College London Hospitals NIHR Biomedical Research Centre. JFS received a UK Medical Research Council project grant (MR/X004724/1) that contributed to the design of the virology study. HA is supported by an NIHR Advanced Fellowship funded by Health and Care Research Wales. JFS has received research grants from the UK Medical Research Council (MR/X004724/1, MR/W015560/1), the Wellcome Trust, NIHR, and the Drugs for Neglected Diseases Initiative, all of which were paid to his institution. OvH has received an NIHR Development and Skills Personal Award. T-AM reports grant funding from Cardiff University through an NIHR award to the University of Oxford. NF reports receiving NIHR grant funding. ML and PL report funding from the NIHR for PANORAMIC. We thank all participants in the study, all participating general practices, NHS COVID-19 treatment services, and other health and social care organisations supporting the trial for their work and support, our patient and public involvement contributors, the trial steering and data monitoring and safety committees, primary care colleagues in the NIHR Clinical Research Network (lead network: Thames Valley and South Midlands), Health and Care Research Wales, NHS Research Scotland, the Health and Social Care Board in Northern Ireland, the NIHR, and the Therapeutics Task Force, NHS DigiTrials, the Intensive Care National Audit and Research Centre, Public Health Scotland, the National Records Service of Scotland, the Secure Anonymised Information Linkage at the University of Swansea, and Health and Social Care Northern Ireland. The views expressed in this Article are the authors' and not necessarily those of the NIHR or the Department of Health and Social Care. Publisher Copyright: © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

Local EPrints ID: 474145

URI: http://eprints.soton.ac.uk/id/eprint/474145

DOI: doi:10.1016/S0140-6736(22)02597-1

ISSN: 0140-6736

PURE UUID: ec0ac215-118f-46ec-acc4-8b327b2265ef

ORCID for Nick Francis: orcid.org/0000-0001-8939-7312

ORCID for Mark Lown: orcid.org/0000-0001-8309-568X

ORCID for Paul Little: orcid.org/0000-0003-3664-1873

Date deposited: 14 Feb 2023 17:40

Last modified: 16 Aug 2024 02:00