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Liver resection for metastatic uveal melanoma: experience from a supra-regional centre and review of literature

Liver resection for metastatic uveal melanoma: experience from a supra-regional centre and review of literature
Liver resection for metastatic uveal melanoma: experience from a supra-regional centre and review of literature

Management of liver metastases from uveal melanoma (LMUM) requires multimodal approach. This study describes evolution of liver resection for LMUM, reviewing current literature and institutional outcomes. Records of patients referred to the Melanoma Multi-Disciplinary Team between February 2005 and August 2018 were reviewed. All publications describing surgery for LMUM were identified from PubMed, Embase, and Google Scholar. Thirty-one of 147 patients with LMUM underwent laparoscopic liver biopsy, and 29 (14 females) had liver resections. Nineteen liver resections were performed locally [7 major (≥3 seg), 14 laparoscopic] without major complications or mortality. Overall survival positively correlated with the time from uveal melanoma to LMUM (Spearman's rho rs  = 0.859, P  < 0.0001). Overall and recurrence-free survivals were comparable following R1 or R0 resections (OS 25 vs. 28 months, P  = 0.404; RFS 13 vs. 6 months, P  = 0.596). R1 resection cohort had longer lead-time (median 100 vs. 24 months, P  = 0.0408). Eleven publications describing liver resection for LMUM were identified and included in the narrative review. Surgery for LMUM is safe and complements multidisciplinary management. Despite heterogeneity in literature, time from diagnosis of uveal melanoma to LMUM remains a key factor affecting survival after liver resection.

Female, Hepatectomy, Humans, Liver Neoplasms/surgery, Melanoma/pathology, Neoplasms, Second Primary, Skin Neoplasms/surgery, Uveal Neoplasms/surgery
0960-8931
71-79
Trivedi, Dharmadev B.
ee82a794-8604-4e7b-be90-1b2f1364e835
Aldulaimi, Natasha
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Karydis, Ioannis
95a2388c-7165-40e1-8b73-87234caea36d
Wheater, Matthew
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Modi, Sachin
caef086a-dda5-418a-ada8-fc042e6e0b18
Stedman, Brian
180a4644-f670-4da1-84db-9d5640e4ec1d
Karavias, Dimitrios
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Primrose, John
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Pearce, Neil
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Takhar, Arjun S.
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Trivedi, Dharmadev B.
ee82a794-8604-4e7b-be90-1b2f1364e835
Aldulaimi, Natasha
6e42cc20-ab03-470e-8878-7b1fdd0d1a93
Karydis, Ioannis
95a2388c-7165-40e1-8b73-87234caea36d
Wheater, Matthew
3691c3d8-8589-4693-a0dc-c6a8648cd7df
Modi, Sachin
caef086a-dda5-418a-ada8-fc042e6e0b18
Stedman, Brian
180a4644-f670-4da1-84db-9d5640e4ec1d
Karavias, Dimitrios
ec27bb13-8e06-45f2-9ea0-2dc5b4c45fce
Primrose, John
d85f3b28-24c6-475f-955b-ec457a3f9185
Pearce, Neil
06acd03a-6ed1-4b9b-851c-391dd50264e4
Takhar, Arjun S.
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Trivedi, Dharmadev B., Aldulaimi, Natasha, Karydis, Ioannis, Wheater, Matthew, Modi, Sachin, Stedman, Brian, Karavias, Dimitrios, Primrose, John, Pearce, Neil and Takhar, Arjun S. (2023) Liver resection for metastatic uveal melanoma: experience from a supra-regional centre and review of literature. Melanoma Research, 33 (1), 71-79. (doi:10.1097/CMR.0000000000000867).

Record type: Article

Abstract

Management of liver metastases from uveal melanoma (LMUM) requires multimodal approach. This study describes evolution of liver resection for LMUM, reviewing current literature and institutional outcomes. Records of patients referred to the Melanoma Multi-Disciplinary Team between February 2005 and August 2018 were reviewed. All publications describing surgery for LMUM were identified from PubMed, Embase, and Google Scholar. Thirty-one of 147 patients with LMUM underwent laparoscopic liver biopsy, and 29 (14 females) had liver resections. Nineteen liver resections were performed locally [7 major (≥3 seg), 14 laparoscopic] without major complications or mortality. Overall survival positively correlated with the time from uveal melanoma to LMUM (Spearman's rho rs  = 0.859, P  < 0.0001). Overall and recurrence-free survivals were comparable following R1 or R0 resections (OS 25 vs. 28 months, P  = 0.404; RFS 13 vs. 6 months, P  = 0.596). R1 resection cohort had longer lead-time (median 100 vs. 24 months, P  = 0.0408). Eleven publications describing liver resection for LMUM were identified and included in the narrative review. Surgery for LMUM is safe and complements multidisciplinary management. Despite heterogeneity in literature, time from diagnosis of uveal melanoma to LMUM remains a key factor affecting survival after liver resection.

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Accepted/In Press date: 15 October 2022
Published date: 1 February 2023
Additional Information: Funding Information: M.W. has received speaker fees from Pierre Fabre and consultancy fees from Bristol Myers Squibb. I.K. received funding in the form of honoraria and travel grants from Delcath Systems Inc. For the remaining authors, there are no conflicts of interest. Publisher Copyright: © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: Female, Hepatectomy, Humans, Liver Neoplasms/surgery, Melanoma/pathology, Neoplasms, Second Primary, Skin Neoplasms/surgery, Uveal Neoplasms/surgery

Identifiers

Local EPrints ID: 474215
URI: http://eprints.soton.ac.uk/id/eprint/474215
ISSN: 0960-8931
PURE UUID: b468a094-5a88-4e69-a2d1-f29318df2bdb
ORCID for John Primrose: ORCID iD orcid.org/0000-0002-2069-7605

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Date deposited: 16 Feb 2023 17:36
Last modified: 17 Mar 2024 07:38

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Contributors

Author: Dharmadev B. Trivedi
Author: Natasha Aldulaimi
Author: Ioannis Karydis
Author: Matthew Wheater
Author: Sachin Modi
Author: Brian Stedman
Author: Dimitrios Karavias
Author: John Primrose ORCID iD
Author: Neil Pearce
Author: Arjun S. Takhar

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