3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder
3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder
3D printed LEGO®-like designs are an attractive approach for the development of compartmental delivery systems due to their potential for dose personalisation through the customisation of drug release profiles. Additive manufacturing technologies such as Fused Deposition Modelling (FDM) are ideal for the printing of structures with complex geometries and various sizes. This study is a paradigm for the fabrication of 3D printed LEGO® -like tablets by altering the design of the modular units and the filament composition for the delivery of different drug substances. By using a combination of placebo and drug loaded compartments comprising of immediate release (hydroxypropyl cellulose) and pH dependant polymers (hypromellose acetate succinate) we were able to customise the release kinetics of melatonin and caffeine that can potentially be used for the treatment of sleeping disorders. The LEGO® -like compartments were designed to achieve immediate release of melatonin followed by variable lag times and controlled release of caffeine.
3D printing, Compartmental systems, LEGO®-like designs, Personalised treatment
Ghanizadeh Tabriz, Atabak
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Sadeque Mithu, Md
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Antonijevic, Milan D
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Vilain, Lilian
952eb376-2384-46e0-b674-e97ac24cdfb9
Derrar, Youri
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Grau, Clara
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Morales, Anaïs
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Katsamenis, Orestis L.
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Douroumis, Dennis
daf9057c-2daa-47a7-b5b5-6b92b00346c1
5 February 2023
Ghanizadeh Tabriz, Atabak
62f41b08-8faf-4897-ab55-1feadab3f707
Sadeque Mithu, Md
d1ffef7f-9916-4ec5-8602-e691f2af9c0e
Antonijevic, Milan D
b5c9b4dd-4e10-404c-b938-84a741b4e241
Vilain, Lilian
952eb376-2384-46e0-b674-e97ac24cdfb9
Derrar, Youri
c8f3a49d-25b7-40d3-a82d-27d9d96d1a57
Grau, Clara
0b7cbe09-9d56-48d8-a24f-af4640b0833c
Morales, Anaïs
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Katsamenis, Orestis L.
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Douroumis, Dennis
daf9057c-2daa-47a7-b5b5-6b92b00346c1
Ghanizadeh Tabriz, Atabak, Sadeque Mithu, Md, Antonijevic, Milan D, Vilain, Lilian, Derrar, Youri, Grau, Clara, Morales, Anaïs, Katsamenis, Orestis L. and Douroumis, Dennis
(2023)
3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder.
International Journal of Pharmaceutics, 632, [122574].
(doi:10.1016/j.ijpharm.2022.122574).
Abstract
3D printed LEGO®-like designs are an attractive approach for the development of compartmental delivery systems due to their potential for dose personalisation through the customisation of drug release profiles. Additive manufacturing technologies such as Fused Deposition Modelling (FDM) are ideal for the printing of structures with complex geometries and various sizes. This study is a paradigm for the fabrication of 3D printed LEGO® -like tablets by altering the design of the modular units and the filament composition for the delivery of different drug substances. By using a combination of placebo and drug loaded compartments comprising of immediate release (hydroxypropyl cellulose) and pH dependant polymers (hypromellose acetate succinate) we were able to customise the release kinetics of melatonin and caffeine that can potentially be used for the treatment of sleeping disorders. The LEGO® -like compartments were designed to achieve immediate release of melatonin followed by variable lag times and controlled release of caffeine.
Text
IJPHARM-D-22-02715
- Author's Original
Text
1-s2.0-S0378517322011292-main
- Version of Record
More information
Accepted/In Press date: 29 January 2022
e-pub ahead of print date: 2 January 2023
Published date: 5 February 2023
Additional Information:
Funding Information:
Beamtime allocation at the μ-VIS X-ray Imaging Centre (www.muvis.org) was supported by the National Research Facility for Lab-based X-ray CT (nxct.ac.uk) through EPSRC grant EP/T02593X/1. The graphical abstract has been created using BioRender.com.
Keywords:
3D printing, Compartmental systems, LEGO®-like designs, Personalised treatment
Identifiers
Local EPrints ID: 474343
URI: http://eprints.soton.ac.uk/id/eprint/474343
ISSN: 0378-5173
PURE UUID: 45d3606f-66d2-4155-8ced-f36b30862027
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Date deposited: 20 Feb 2023 17:54
Last modified: 17 Mar 2024 03:24
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Contributors
Author:
Atabak Ghanizadeh Tabriz
Author:
Md Sadeque Mithu
Author:
Milan D Antonijevic
Author:
Lilian Vilain
Author:
Youri Derrar
Author:
Clara Grau
Author:
Anaïs Morales
Author:
Dennis Douroumis
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