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Dominant genes for colorectal cancer are not rare

Dominant genes for colorectal cancer are not rare
Dominant genes for colorectal cancer are not rare
The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0·006 with a lifetime penetrance of 0·63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.
0003-4800
99-103
Houlston, R. S.
0292e06f-2fd2-4b71-a629-00b288016474
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Slack, J.
ecb80405-9ad4-46b2-b2a8-813a82dc2981
Morton, N. E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Houlston, R. S.
0292e06f-2fd2-4b71-a629-00b288016474
Collins, Andrew
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Slack, J.
ecb80405-9ad4-46b2-b2a8-813a82dc2981
Morton, N. E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7

Houlston, R. S., Collins, Andrew, Slack, J. and Morton, N. E. (1992) Dominant genes for colorectal cancer are not rare. Annals of Human Genetics, 56 (2), 99-103. (doi:10.1111/j.1469-1809.1992.tb01136.x).

Record type: Article

Abstract

The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0·006 with a lifetime penetrance of 0·63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.

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Published date: May 1992
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Local EPrints ID: 474747
URI: http://eprints.soton.ac.uk/id/eprint/474747
DOI: doi:10.1111/j.1469-1809.1992.tb01136.x
ISSN: 0003-4800
PURE UUID: 27c639e8-151a-4e1d-a649-1a3e620baa3f
ORCID for Andrew Collins: ORCID iD orcid.org/0000-0001-7108-0771

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Date deposited: 02 Mar 2023 17:39
Last modified: 17 Mar 2024 02:38

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Contributors

Author: R. S. Houlston
Author: Andrew Collins ORCID iD
Author: J. Slack
Author: N. E. Morton

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