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Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study

Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study
Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study
Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.
1055-9965
740-746
Chang-Claude, Jenny
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Andrieu, Nadine
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Rookus, Matti
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Brohet, Richard
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Davidson, Rosemarie
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Eccles, Diana
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Lucassen, Anneke
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Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study
Chang-Claude, Jenny
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Andrieu, Nadine
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Rookus, Matti
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Brohet, Richard
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Antoniou, Antonis C.
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Peock, Susan
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Davidson, Rosemarie
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Izatt, Louise
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Cole, Trevor
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Noguès, Catherine
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Luporsi, Elisabeth
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Huiart, Laetitia
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Hoogerbrugge, Nicoline
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Van Leeuwen, Flora E.
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Osorio, Ana
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Eyfjord, Jorunn
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Radice, Paolo
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Goldgar, David E.
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Easton, Douglas F.
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Wagner, Teresa
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Korn, Verena
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Gerdes, Anne Marie
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Olah, Edith
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Eyford, Jorunn
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Manoukian, Siranonoush
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Pierotti, Marco A.
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Benitez, Javier
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Caldes, Trinidad
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De La Hoya, Miguel
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Lubinski, Jan
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Arver, Brita
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Olsson, H.
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Loman, Niklas
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Simard, Jacques
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Sibille, Catherine
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Van Asperen, Christi
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Meijers-Heijboer, Hanne
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Verhoef, Senno
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Vasen, Hans
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Ausems, Margreet
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Menko, Fred
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Gomez-Garcia, Encarna
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Cook, Margaret
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Engel, Cassandra
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Gregory, Helen
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Gray, Jonathan
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Evans, Gareth
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Eccles, Diana
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Lucassen, Anneke
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Chang-Claude, Jenny, Andrieu, Nadine, Rookus, Matti, Brohet, Richard, Gray, Jonathan, Evans, Gareth, Eccles, Diana and Lucassen, Anneke , Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (2007) Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study. Cancer Epidemiology Biomarkers and Prevention, 16 (4), 740-746. (doi:10.1158/1055-9965.EPI-06-0829).

Record type: Article

Abstract

Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.

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Published date: 1 April 2007

Identifiers

Local EPrints ID: 474769
URI: http://eprints.soton.ac.uk/id/eprint/474769
ISSN: 1055-9965
PURE UUID: f3e2ad53-24fa-40dd-b4e8-d85a62f3fc37
ORCID for Diana Eccles: ORCID iD orcid.org/0000-0002-9935-3169
ORCID for Anneke Lucassen: ORCID iD orcid.org/0000-0003-3324-4338

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Date deposited: 02 Mar 2023 17:46
Last modified: 17 Mar 2024 02:54

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Contributors

Author: Jenny Chang-Claude
Author: Nadine Andrieu
Author: Matti Rookus
Author: Richard Brohet
Author: Antonis C. Antoniou
Author: Susan Peock
Author: Rosemarie Davidson
Author: Louise Izatt
Author: Trevor Cole
Author: Catherine Noguès
Author: Elisabeth Luporsi
Author: Laetitia Huiart
Author: Nicoline Hoogerbrugge
Author: Flora E. Van Leeuwen
Author: Ana Osorio
Author: Jorunn Eyfjord
Author: Paolo Radice
Author: David E. Goldgar
Author: Douglas F. Easton
Author: Teresa Wagner
Author: Verena Korn
Author: Anne Marie Gerdes
Author: Edith Olah
Author: Jorunn Eyford
Author: Siranonoush Manoukian
Author: Marco A. Pierotti
Author: Javier Benitez
Author: Trinidad Caldes
Author: Miguel De La Hoya
Author: Jan Lubinski
Author: Brita Arver
Author: H. Olsson
Author: Niklas Loman
Author: Jacques Simard
Author: Catherine Sibille
Author: Christi Van Asperen
Author: Hanne Meijers-Heijboer
Author: Senno Verhoef
Author: Hans Vasen
Author: Margreet Ausems
Author: Fred Menko
Author: Encarna Gomez-Garcia
Author: Margaret Cook
Author: Cassandra Engel
Author: Neva Haites
Author: Helen Gregory
Author: Jonathan Gray
Author: Gareth Evans
Author: Diana Eccles ORCID iD
Author: Anneke Lucassen ORCID iD
Corporate Author: Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study

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