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COGENT (COlorectal cancer GENeTics) revisited

COGENT (COlorectal cancer GENeTics) revisited
COGENT (COlorectal cancer GENeTics) revisited

Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.

0267-8357
143-151
Houlston, R. S.
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Tomlinson, I.
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et al.
Houlston, R. S.
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Buch, S.
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Radice, P.
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Li, L.
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Echeverry, M. M.
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Bohorquez, M.
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Evans, Gareth
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Lucassen, Anneke
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Green, Andrew
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Muñoz, Raquel
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Houlston, R. S., Tomlinson, I., Dunlop, M., Evans, Gareth, Lucassen, Anneke, Green, Andrew and Muñoz, Raquel , et al. (2012) COGENT (COlorectal cancer GENeTics) revisited. Mutagenesis, 27 (2), 143-151. (doi:10.1093/mutage/ger059).

Record type: Article

Abstract

Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT.

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More information

Published date: 1 March 2012
Additional Information: Funding Information: supported by grants from Cancer Research Wales to J.P.C. and Tenovus to J.P.C. We acknowledge the use of DNA from the UKBS, funded by the Wellcome Trust (grant 06113/C/04/Z); by the Juvenile Diabetes Research Foundation grant WT061858 and by the National Institute of Health Research of England. In Spain, work is supported by grants from the Instituto de Salud Carlos III, grants FIS 05/1006, 08/1359, 08/ 1635 and European Commission FP6 Food-CT-2006-036224 to V.M.. In Canada, work is supported by grants from the Ontario Research Fund from the Ontario Ministry of Research and Innovation, The Canadian Cancer Society Research Institute, the Canadian Institutes of Health Research and the Ontario Institute for Cancer Research. In Finland, work is supported by grants from Academy of Finland (Finnish Centre of Excellence Program 2006–2011), the Sigrid Juselius Foundation, the Finnish Cancer Societies and the European Union. Funding Information: The work of the DFKS is supported by the German Genome Network (NGFNplus). In the Czech Republic, work is supported by GACR 310/07/1430 and P304/10/1286. In Sweden, work is supported by grants from the Swedish Cancer Foundation and the Swedish Research Council. In Barcelona and Santiago (Epicolon), work is supported by grants from Fondo de Investigación Sanitaria/FEDR (08/0024, 08/1276, PS09/02368, 11/00219, 11/0068), Xunta de Galicia (PGI-DIT07PXIB9101209PR), Ministerio de Educación y Ciencia (SAF2010-19273), Asociación Española contra el Cáncer (Fundación Cientifica y Junta de Barcelona) Fundación Olga Torres to C.R.P. and Acción Transversal contra el Cáncer (Instituto de Salud Carlos III) and FP& CHIBCHA Constrotium to S.C.B. and Angel Carracedo CIBERER and CIBEREHD are funded by the Instituto de Salud Carlos III. S.C.B. is supported by a contract from the Fondo de Investigación Sanitaria (CP 03-0070, Ministerio de Sanidad). The work was carried out (in part) at the Esteher Koplowtiz Centre, Barcelona. In the Netherlands, work of R.M.W.H is supported by the Dutch Cancer Society, the European Community, and the work of J.T.W., T.vW., H.M. and PD by the Dutch Cancer Society (UL2005-3247) and Fonds NutsOhra. In Hong Kong, work is supported by grants from the Michael and Betty Kadoorie Cancer Genetics Research Programme II; and the Bobby Moore Fund of Cancer Research UK. Work in Australia is conducted under the auspices of the Hilton Ludwig Cancer Metastasis Initiative and supported by a grant from the NHMRC (Project Grant 489418). In Japan, this work was conducted as a part of the BioBank Japan Project that was supported by the Ministry of Education, Culture, Sports, Sciences and Technology of Japanese government. The ESTHER and VERDI studies are supported by grants from the Baden Württemberg Ministry of Research, Science and Arts and the German Cancer Aid (Deutsche Krebshilfe), grant M24/95/BR I. The Kiel cohort (POPGEN) is funded through the German Ministry of Education and Reserach through the POPGEN Biobank grant and the Colon Cancer Network of the German National Genome Research Network. SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research, the Ministry of Cultural Affairs as well as the Social Ministry of the Federal State of Mecklen-burg-West Pomerania. Genome-wide data have been supported by the Federal Ministry of Education and Research (grant no. 03ZIK012) and a joint grant from Siemens Healthcare, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. The University of Greifswald is a member of the ‘Center of Knowledge Interchange’ program of the Siemens AG. M.M.E., A.V. and L.C.-C. have received funding from Cancer Research UK and Universidad del Tolima. This study is supported by grants from Associazione/Fondazione Italiana per la Ricerca sul Cancro (AIRC/FIRC). The Kentucky Colon Cancer Genetic Epidemiology Study is supported by grants from the National Cancer Institute (CA136726) and the Damon-Runyon Cancer Research Foundation (CI-8). Funding Information: The work of UK groups is supported by grants from Cancer Research UK and the European Union. In Wales, work is

Identifiers

Local EPrints ID: 474792
URI: http://eprints.soton.ac.uk/id/eprint/474792
ISSN: 0267-8357
PURE UUID: 0403f74d-520d-4f7b-883f-0ccd97dad845
ORCID for Anneke Lucassen: ORCID iD orcid.org/0000-0003-3324-4338

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Date deposited: 02 Mar 2023 17:49
Last modified: 18 Mar 2024 02:54

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Contributors

Author: R. S. Houlston
Author: I. Tomlinson
Author: M. Dunlop
Author: H. Campbell
Author: B. Zanke
Author: S. Gallinger
Author: T. Hudson
Author: T. Koessler
Author: P. D. Pharoah
Author: I. Niittymäki
Author: S. Tuupanen
Author: L. A. Aaltonen
Author: K. Hemminki
Author: A. Lindblom
Author: A. Försti
Author: O. Sieber
Author: L. Lipton
Author: T. van Wezel
Author: H. Morreau
Author: J. T. Wijnen
Author: P. Devilee
Author: K. Matsuda
Author: Y. Nakamura
Author: S. Castellví-Bel
Author: C. Ruiz-Ponte
Author: A. Castells
Author: Angel Carracedo
Author: J. W.C. Ho
Author: P. Sham
Author: P. Vodicka
Author: H. Brenner
Author: J. Hampe
Author: C. Schafmayer
Author: J. Tepel
Author: S. Schreiber
Author: H. Völzke
Author: M. M. Lerch
Author: C. A. Schmidt
Author: S. Buch
Author: V. Moreno
Author: C. M. Villanueva
Author: P. Peterlongo
Author: P. Radice
Author: L. Li
Author: M. M. Echeverry
Author: M. Bohorquez
Author: Gareth Evans
Author: Anneke Lucassen ORCID iD
Author: Andrew Green
Author: Raquel Muñoz
Corporate Author: et al.

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