Orchestration of adaptive T Cell responses by neutrophil granule contents.
Orchestration of adaptive T Cell responses by neutrophil granule contents.
Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. We consider how the release of granule contents by neutrophils—through NETosis or degranulation—is one way in which the innate immune system directs the phenotype of the adaptive immune response.
Minns, Danielle
ce196311-8b43-442a-99b5-1568f019a5bd
Smith, Katie J.
11038f91-35d1-4999-9c3a-15f62f13585a
Gwyer Findlay, Emily
b6787bbb-66ad-435c-ad2c-c18ffaf6b7d8
March 2019
Minns, Danielle
ce196311-8b43-442a-99b5-1568f019a5bd
Smith, Katie J.
11038f91-35d1-4999-9c3a-15f62f13585a
Gwyer Findlay, Emily
b6787bbb-66ad-435c-ad2c-c18ffaf6b7d8
Minns, Danielle, Smith, Katie J. and Gwyer Findlay, Emily
(2019)
Orchestration of adaptive T Cell responses by neutrophil granule contents.
Mediators of Inflammation, 2019, [8968943].
(doi:10.1155/2019/8968943).
Abstract
Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. We consider how the release of granule contents by neutrophils—through NETosis or degranulation—is one way in which the innate immune system directs the phenotype of the adaptive immune response.
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Published date: March 2019
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Local EPrints ID: 474801
URI: http://eprints.soton.ac.uk/id/eprint/474801
ISSN: 0962-9351
PURE UUID: a696ac11-a524-472c-a656-e0bb5fcfdd3f
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Date deposited: 03 Mar 2023 17:31
Last modified: 17 Mar 2024 04:14
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Author:
Danielle Minns
Author:
Katie J. Smith
Author:
Emily Gwyer Findlay
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