Factors influencing innate immunity and vaccine responses in infancy
Factors influencing innate immunity and vaccine responses in infancy
Despite significant progress in reducing the burden of mortality in children under the age of five, reducing mortality in newborns remains a major challenge. Infection plays a significant role in infant deaths and interventions such as early vaccination or antenatal immunization could make a significant contribution to prevention of such deaths. In the last fewyears, we have gained newinsights into immune ontogeny and are nowbeginning to understand the impact of vaccines, nutrition and environmental factors on ‘training0 of the immune response in early life. This review article sets out to explain why vaccine responses can be heterogeneous between populations and individuals by providing examples chosen to illustrate the impact of host, pathogen and environmental factors on shaping theimmune ‘interactome0 in young children.
BCG vaccine, Immune ontogeny, Maternal immunization, Vaccine responses
Kampmann, Beate
4490f5e3-318c-4074-bf69-4a23bd5ec100
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
19 June 2015
Kampmann, Beate
4490f5e3-318c-4074-bf69-4a23bd5ec100
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
Kampmann, Beate and Jones, Christine E.
(2015)
Factors influencing innate immunity and vaccine responses in infancy.
Philosophical Transactions of the Royal Society B: Biological Sciences, 370 (1671), [20140148].
(doi:10.1098/rstb.2014.0148).
Abstract
Despite significant progress in reducing the burden of mortality in children under the age of five, reducing mortality in newborns remains a major challenge. Infection plays a significant role in infant deaths and interventions such as early vaccination or antenatal immunization could make a significant contribution to prevention of such deaths. In the last fewyears, we have gained newinsights into immune ontogeny and are nowbeginning to understand the impact of vaccines, nutrition and environmental factors on ‘training0 of the immune response in early life. This review article sets out to explain why vaccine responses can be heterogeneous between populations and individuals by providing examples chosen to illustrate the impact of host, pathogen and environmental factors on shaping theimmune ‘interactome0 in young children.
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Accepted/In Press date: 30 March 2015
Published date: 19 June 2015
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Publisher Copyright:
© 2015 The Author(s) Published by the Royal Society. All rights reserved.
Keywords:
BCG vaccine, Immune ontogeny, Maternal immunization, Vaccine responses
Identifiers
Local EPrints ID: 474802
URI: http://eprints.soton.ac.uk/id/eprint/474802
ISSN: 0962-8436
PURE UUID: d4851fe9-5384-449e-bd34-b041775ccade
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Date deposited: 03 Mar 2023 17:31
Last modified: 17 Mar 2024 03:45
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Author:
Beate Kampmann
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