Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants
Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants
Background: BCG vaccination prevents disseminated tuberculosis in children, but it is contraindicated for persons with human immunodeficiency virus (HIV) infection because it can result in severe disease in this population. In tuberculosis-endemic regions, BCG vaccine is administered soon after birth, before in utero and peripartum HIV infection is excluded. We therefore assessed the immunogenicity of BCG vaccine in HIV-exposed infants who received BCG at birth or at 8 weeks of age.
Methods: HIV-exposed, uninfected infants were randomly assigned to receive BCG vaccination at birth (the early vaccination arm) or 8 weeks of age (the delayed vaccination arm). BCG-specific proliferative and intracellular cytokine responses were assessed in 28 infants per arm at 6, 8, and 14 weeks of life. Results: There was no difference in BCG-specific T-cell proliferation between the study arms 6 weeks after vaccination. However, at 14 weeks of age, the frequency of interferon γ-expressing CD4+ T cells and multifunctional BCG-specific responses in the delayed vaccinated arm were significantly higher than those in the early vaccination arm (P =. 021 and P =. 011, respectively). Conclusions.The immunogenicity of BCG vaccination in HIV-exposed, uninfected infants is not compromised when delayed until 8 weeks of age and results in robust BCG-specific T-cell responses at 14 weeks of age. These findings support further evaluation of this modified BCG vaccination strategy for HIV-exposed infants. Clinical Trials Registration.NCT02062580.
BCG vaccination, infants, intracellular cytokines, maternal HIV, T-cell proliferation
338-346
Tchakoute, Christophe Toukam
66ef1bb9-de5e-4ba7-aeee-ed64589aa1e6
Hesseling, Anneke C.
f97382e1-ac66-4c60-aa47-153f2ea687df
Kidzeru, Elvis B.
df4d427c-3759-4c51-9a93-36ed4c1d2410
Gamieldien, Hoyam
52c7f078-3241-49e7-919c-76a11a46de82
Passmore, Jo Ann S.
93936ac8-a5b3-472a-aa0b-6f1e4c9222eb
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
Gray, Clive M.
820faf74-2bcd-4686-a810-4a3efd720560
Sodora, Donald L.
5f0fd686-cd20-4949-85a6-33f1eec0a46f
Jaspan, Heather B.
1fe68fa8-c1e3-4fe6-ac2f-1e6c2178cdd5
1 February 2015
Tchakoute, Christophe Toukam
66ef1bb9-de5e-4ba7-aeee-ed64589aa1e6
Hesseling, Anneke C.
f97382e1-ac66-4c60-aa47-153f2ea687df
Kidzeru, Elvis B.
df4d427c-3759-4c51-9a93-36ed4c1d2410
Gamieldien, Hoyam
52c7f078-3241-49e7-919c-76a11a46de82
Passmore, Jo Ann S.
93936ac8-a5b3-472a-aa0b-6f1e4c9222eb
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
Gray, Clive M.
820faf74-2bcd-4686-a810-4a3efd720560
Sodora, Donald L.
5f0fd686-cd20-4949-85a6-33f1eec0a46f
Jaspan, Heather B.
1fe68fa8-c1e3-4fe6-ac2f-1e6c2178cdd5
Tchakoute, Christophe Toukam, Hesseling, Anneke C., Kidzeru, Elvis B., Gamieldien, Hoyam, Passmore, Jo Ann S., Jones, Christine E., Gray, Clive M., Sodora, Donald L. and Jaspan, Heather B.
(2015)
Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants.
Journal of Infectious Diseases, 211 (3), .
(doi:10.1093/infdis/jiu434).
Abstract
Background: BCG vaccination prevents disseminated tuberculosis in children, but it is contraindicated for persons with human immunodeficiency virus (HIV) infection because it can result in severe disease in this population. In tuberculosis-endemic regions, BCG vaccine is administered soon after birth, before in utero and peripartum HIV infection is excluded. We therefore assessed the immunogenicity of BCG vaccine in HIV-exposed infants who received BCG at birth or at 8 weeks of age.
Methods: HIV-exposed, uninfected infants were randomly assigned to receive BCG vaccination at birth (the early vaccination arm) or 8 weeks of age (the delayed vaccination arm). BCG-specific proliferative and intracellular cytokine responses were assessed in 28 infants per arm at 6, 8, and 14 weeks of life. Results: There was no difference in BCG-specific T-cell proliferation between the study arms 6 weeks after vaccination. However, at 14 weeks of age, the frequency of interferon γ-expressing CD4+ T cells and multifunctional BCG-specific responses in the delayed vaccinated arm were significantly higher than those in the early vaccination arm (P =. 021 and P =. 011, respectively). Conclusions.The immunogenicity of BCG vaccination in HIV-exposed, uninfected infants is not compromised when delayed until 8 weeks of age and results in robust BCG-specific T-cell responses at 14 weeks of age. These findings support further evaluation of this modified BCG vaccination strategy for HIV-exposed infants. Clinical Trials Registration.NCT02062580.
This record has no associated files available for download.
More information
Published date: 1 February 2015
Additional Information:
This work was supported by the Elizabeth Glaser Pediatric AIDS Foundation (grant MV-00-9-900-01871-0-00), a Thrasher Foundation Early Career Award (grant NR-0095 to H. B. J.), a Canadian African Prevention Trials Network Scholarship (to C. T. T.), and the Poliomyelitis Research Foundation Fellowship (to E. B. K.).
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. please e-mail:
journals.permissions@oup.com
Keywords:
BCG vaccination, infants, intracellular cytokines, maternal HIV, T-cell proliferation
Identifiers
Local EPrints ID: 474807
URI: http://eprints.soton.ac.uk/id/eprint/474807
ISSN: 0022-1899
PURE UUID: e9c8d0c1-cd34-4b88-9844-88cd7e8af208
Catalogue record
Date deposited: 03 Mar 2023 17:32
Last modified: 17 Mar 2024 03:45
Export record
Altmetrics
Contributors
Author:
Christophe Toukam Tchakoute
Author:
Anneke C. Hesseling
Author:
Elvis B. Kidzeru
Author:
Hoyam Gamieldien
Author:
Jo Ann S. Passmore
Author:
Clive M. Gray
Author:
Donald L. Sodora
Author:
Heather B. Jaspan
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
